Synthesis and Biological Evaluation of Pyrazolo[1,5-a]pyrimidine Compounds as Potent and Selective Pim-1
Inhibitors |
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| Authors: | Yong Xu,Benjamin G. Brenning,Steven G. Kultgen,Jason
M. Foulks,Adrianne Clifford,Shuping Lai,Ashley Chan,Shannon Merx,Michael V. McCullar,Steven B. Kanner,Koc-Kan Ho |
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| Affiliation: | Astex Pharmaceuticals, Inc., 4140 Dublin Boulevard, Suite 200, Dublin, California 94568 United States |
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| Abstract: | ![]()
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| Keywords: | Pyrazolo[1,5-a]pyrimidine Pim-1 inhibitor BAD phosphorylation 2-dimensionalcolony formation hERG inhibition kinase selectivity |
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