氟哌噻吨美利曲辛片联合泮托拉唑胶囊和枸橼酸莫沙必利治疗非糜烂性胃食管反流病的临床分析

目的探讨氟哌噻吨美利曲辛片联合泮托拉唑胶囊和枸橼酸莫沙必利治疗非糜烂性胃食管反流病（NERD）的临床疗效。方法选择中国核工业北京四。一医院2011年6月至2013年6月确诊的184例NERD患者，按照随机数字表将患者随机分为试验组（92例）和对照组（92例）：对照组给予泮托拉唑胶囊（40mg/次，1次／d，口服）联合枸橼酸莫沙必利（3次／d，口服）治疗，试验组在对照组的基础上给予氟哌噻吨美利曲辛片（10．5mg／次，1次／d，首剂量翻倍，口服）治疗。2组患者均以1个月为1个疗程，连续治疗2个疗程。，治疗后比较2组患者的治疗效果和3种症状积分情况。结果治疗后2组患者的烧心、反酸、胸痛积分均优于治疗前，差异均有统计学意义（均P〈0．05），且试验组患者的烧心、反酸、胸痛积分（0．26±1．01、0、0）均优于对照组（0．95±1．25、0．72±0．98、0．85±0．54），差异均有统计学意义（均P〈0．05）。试验组患者治疗后总有效例数为89例，总有效率为96．7％；对照组治疗后总有效例数为80例，总有效率为87．0％，2组总有效率比较差异有统计学意义（χ2=5．879，P〈0．05）。试验组92例中有14例患者病情复发，复发率（15．2％）明显低于对照组（34．8％，32／92），差异有统计学意义（χ2=9．391，P〈0．05）。结论NERD与众多因素相关，氟哌噻吨美利曲辛片联合泮托拉唑胶囊和枸橼酸莫沙必利的治疗效果优于泮托拉唑胶囊联合枸橼酸莫沙必利的治疗效果，联合用药可提高治疗效果、降低复发率。

Clinical analysis of flupentixol and melitracen tablets combined with pantoprazole capsule and mosapride citrate treating non-erosive gastroesophageal reflux disease

Objective To explore the clinical effects of flupentixol and melitraeen tablets combined with pantoprazole capsule and mosapride citrate on non-erosive gastroesophageal reflux disease （NERD）. Methods Totally 184 patients from June 2011 to June 2013 were confirmed with NERD and randomly divided into experiment group （ n = 92） and control group （ n = 92）. Control group had pantoprazole capsule（40 mg/time/day, oral administration） combined with mosapride citrate （5 rag/time, 3 timesdaily, oral administration ） ; the experimental group had flupentixol and melitracen tablets. The curative effect and three kinds of symptom integral situation of two groups were compared after treatment. Results After treatment, the symptoms of acid reflux, heart- burn and chest pain in two groups were improved （P 〈 0.05 ） ; the experiment group （0.26 ± 1.01,0,0） were su- perior to the control group （0.95± 1.25,0.72 ± 0.98,0.85 ± 0.54） （P 〈 0.05 ）. The effective rate was significantly higher in experiment group（89 cases of effective） than in the control group（80 cases of effective）. NERD patients clinical effective rate was 96.7% （n = 89） , while the control group after treatment the clinical effective rate was 87.0% （ n = 80） ; the results of two groups had statistically significant difference （χ2 = 5. 879,P 〈 0.05 ）. The recurrence rates（ 14 cases, 15.2% ） in the experimental group were significantly lower than in the control group （32 cases,34.8% ） （χ2 = 9. 391 ,P 〈 0.05 ）. Conclusions The NERD is associated with many factors. The effective rate is significantly higher in the experiment group than in the control group; combination therapy can improve efficacy and reduce recurrence rate.