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Successful early intervention for hyperacute transplant‐associated thrombotic microangiopathy following pediatric hematopoietic stem cell transplantation |
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| Authors: | Sonata Jodele Jack J. Bleesing Parinda A. Mehta Alexandra H. Filipovich Benjamin L. Laskin Jens Goebel Susan L. Pinkard Stella M. Davies |
| Affiliation: | 1. Divisions of Bone Marrow Transplant and Immune Deficiency;2. Nephrology and Hypertension, Cincinnati Children’s Hospital Medical Center;3. Hoxworth Blood Center, University of Cincinnati, Cincinnati, OH, USA |
| Abstract: | Jodele S, Bleesing JJ, Mehta PA, Filipovich AH, Laskin BL, Goebel J, Pinkard SL, Davies SM. Successful early intervention for hyperacute transplant‐associated thrombotic microangiopathy following pediatric hematopietic stem cell transplantation. Pediatr Transplantation 2012: 16: E39–E42. © 2010 John Wiley & Sons A/S. Abstract: TA‐TMA is a serious complication of hematopoietic stem cell transplantation, presenting as microangiopathic hemolytic anemia with severe renal injury and mortality as high as 60%. Diagnosis and treatment of TA‐TMA is very challenging after HSCT because anemia, thrombocytopenia, hypertension, and renal impairment are multifactorial, leading to delayed recognition and management of this complication. We report a successful outcome following early intervention for hyperacute TA‐TMA after allogeneic HSCT. |
| Keywords: | transplant‐associated thrombotic microangiopathy TA‐TMA hematopoietic stem cell transplantation pediatrics |