妇科恶性肿瘤患者组织因子及其途径抑制物与术后深静脉血栓形成的关系

目的:对妇科肿瘤患者的组织因子（tissue factor，TF）、组织因子抑制物（tissue factor pathway inhibitor，TFPI）的水平含量进行测定，探究其与妇科恶性肿瘤术后深静脉血栓形成的关系。方法:选取2013年1月至2015年1月我院收治的73例妇科恶性肿瘤患者作为本次研究的对象，选取同期于我院接受体检的50例健康妇女作为对照组，采用ELISA法对所有研究对象的TF、TFPI抑制物水平进行检测，同时分析二者与深静脉血栓形成的关系。结果:研究中有9例患者在术后发生深静脉血栓，其中宫颈癌患者4例，子宫内膜癌患者3例，卵巢癌患者2例。全部类型的妇科恶性肿瘤患者的血浆TF、血浆TFPI-1水平以及TFPI活性均显著高于对照组（P<0.05）；对照组的TFPI-1水平显著低于有、无深静脉血栓组，而TF水平显著低于有深静脉血栓组（P<0.05）；无深静脉血栓组的TF、TFPI-1水平均显著低于有深静脉血栓组（P<0.05）。结论:妇科肿瘤术后深静脉血栓形成的患者血浆TF、TFPI-1水平显著增高，可将TF、TFPI-1作为预测深静脉血栓形成的重要检测指标。

The relationship between deep vein thrombosis and tissue factor or tissue factor pathway inhibitor in gynecologic cancer patients

Objective:To measure the levels of tissue factor（TF），tissue factor pathway inhibitor（TFPI） of gynecologic tumor patients and to explore its relationship with gynecological malignant tumor postoperative deep venous thrombosis.Methods:From January 2013 to January 2015 in our hospital from 73 cases of gynecological malignant tumor patients as the research object，select the same period in our hospital in our hospital underwent a medical examination of 50 cases of healthy women as the control group.Of all the subjects of the study of TF，TFPI levels were detected by enzyme-linked immunosorbent assay(ELISA)，and to analyze the relationship of the two and deep vein thrombosis.Results:In 9 cases of patients with postoperative deep venous thrombosis，there were 4 cases of patients with cervical cancer，3 cases of endometrial carcinoma，2 cases of ovarian cancer patients.All types of gynecological malignant tumor patients with plasma levels of TF and plasma TFPI-1 levels and TFPI activity were significantly higher than those in the control group(P<0.05).Control group of TFPI-1 levels were significantly lower than deep or no deep venous thrombosis group，and TF levels was significantly lower than that of deep vein thrombosis group(P<0.05). No deep venous thrombosis group of TF，TFPI-1 levels were significantly lower than deep venous thrombosis group(P<0.05).Conclusion:The plasma TF and TFPI-1 levels were significantly increased in patients with deep venous thrombosis after gynecological tumor surgery.TFPI-1 and TF could be used as the important indicators to predict the formation of deep venous students.