局部应用多西环素对脱位恒牙愈合效果的影响

目的 评价使用多西环素和生理盐水处理脱位恒牙对牙髓及牙周愈合的影响。方法 将38例患者（男22例,女16例,年龄7~14岁）的44颗脱位恒牙随机分为2组。在复位植入牙槽窝前,A组21颗牙使用0.05 mg/mL多西环素溶液浸泡5 min,B组23颗牙使用生理盐水浸泡5 min。术后定期随访并观察牙根发育情况, 使用Mann-Whitney U检验评价2组愈合情况的差异。结果 2组脱位牙之间的基本特征无显著差异。A组18颗牙被诊断为牙髓坏死,3颗牙有炎症性吸收,13颗牙有骨性黏连,6颗被拔除。B组16颗牙被诊断为牙髓坏死,4颗牙有炎症性吸收,12颗牙有骨性黏连,7颗被拔除。2组间的主要临床随访结局差异无统计学意义。结论 与生理盐水相比,使用多西环素溶液处理脱位恒牙并未显示出明显的优势。

Effects of topical application of doxycycline on avulsed permanent teeth

PURPOSE: To evaluate the treatment effect of topical doxycycline on avulsed permanent teeth compared with normal saline. METHODS: A total of 44 avulsed teeth from 38 patients (22 boys and 16 girls, aged 7-14 years) were recruited. Twenty-one teeth in group A were treated with doxycycline for 5 min before replantation while 23 teeth in group B were treated with saline solution. All participants were followed up for at least 12 months. The clinical outcome differences between 2 groups was evaluated by Mann-Whitney U test. RESULTS: In group A, 18 teeth were found pulp necrosis, 3 with infection-related resorption, 13 with ankylosis-related resorption and 6 were extracted. In group B, 16 were diagnosed with pulp necrosis, 4 with infection-related resorption, 12 with ankylosis-related resorption and 7 were extracted. No significant differences were found between the two groups on pulp survival and periodontal healing. CONCLUSIONS: Compared with treatment with normal saline, avulsed permanent teeth treated with doxycycline did not show a better clinical outcome.