MGMT基因多态性与前列腺癌易感性的Meta分析

目的:探讨6-甲基鸟嘌呤甲基转移酶(6O-methylguanine-DNA methyltransferase,MGMT)基因多态性与前列腺癌（prostate cancer，PCa）发病易感性的关联。方法:通过检索PubMed、CNKI和万方数据库从1970年1月1日至2016年12月31日国内外已经公开发表的中、英文献，筛选合格文献行Meta分析。结果:最终纳入关于MGMT基因多态性与PCa易感性关联的病例-对照研究11项，共计病例组5 143例，对照组8 118例。Meta分析结果显示，MGMT基因rs12917多态性位点与PCa显著相关(TT vs CC:P=0.047,TT vs CC+CT:P=0.038)。以种族进行亚组分析显示，MGMT基因rs12917多态性位点在亚洲人中与PCa显著相关（T vs C:P=0.008,TC vs CC:P=0.013,TC+TT vs CC:P=0.009,TC vs CC+TT:P=0.014）。然而MGMT基因的rs2308327和rs2308321多态性位点和PCa的易感性无关。结论:本Meta分析结果认为MGMT基因rs12917多态性位点与PCa的易感性相关，可作为PCa患者潜在的诊断、筛查分子标志物。

Association between polymorphisms in MGMT and prostate cancer susceptibility:A Meta-analysis

Objective:To explore the relevance between MGMT polymorphisms and prostate cancer susceptibility.Methods:We retrieved PubMed，CNKI and Wanfang databases to search for all eligible studies published from Jan 1，1970 to 0ct 31，2016 to conduct a Meta-analysis.Results:A total of 11 case-control studies were enrolled，including 5 143 cases and 8 118 controls.Our work demonstrated that rs12917 polymorphisms in MGMT significantly associated with prostate cancer susceptibility(TT vs CC:P=0.047,TT vs CC+CT:P=0.038).In the stratification analysis by ethnicity，we identified an increased risk of rs12917 polymorphism and prostate cancer susceptibility in Asian population（T vs C:P=0.008,TC vs CC:P=0.013,TC+TT vs CC:P=0.009,TC vs CC+TT:P=0.014）.However，no association was identified between rs2308327 and rs2308321 polymorphisms in MGMT and prostate cancer susceptibility.Conclusion:There is a positive relevance between rs12917 polymorphisms and prostate cancer susceptibility，which can serve as a diagnosis and screening molecular biomarker for prostate cancer patients.