广泛期小细胞肺癌一线化疗肿瘤缓解深度与生存期的相关性

目的:分析广泛期小细胞肺癌一线化疗后肿瘤缓解深度与患者生存期的相关性。方法:回顾性分析符合入组条件的50例初治广泛期小细胞肺癌患者的临床资料。通过Spearman秩相关检验评价广泛期小细胞肺癌化疗后肿瘤缓解深度与生存期的相关性,应用Log-rank检验比较不同肿瘤缓解深度对生存期的影响,应用COX比例回归模型进行多因素分析。结果:Spearman秩相关分析显示肿瘤缓解深度与PFS及OS均呈中等程度相关。不同缓解深度患者的生存期存在统计学差异。体重减少(P <0. 000 1)、缓解深度(P<0. 001)为无进展生存期的独立影响因素;体重减少(P <0. 000 1)、体力状态(P=0. 001 2)、缓解深度(P <0. 001)、化疗周期(P=0. 000 2)、二线治疗(P=0. 006 7)为总生存期的独立预后因素。结论:广泛期小细胞肺癌一线化疗后肿瘤缓解深度对患者生存期有一定的预测价值。

Correlation between depth of tumour response and survival in extensive stage SCLC

Objective:To assess the relationship between depth of response and survival in extensive stage SCLC after first-line therapy.Methods:50 patients with extensive stage SCLC were included in the retrospective analysis.Spearman rank correlation was used to evaluate the relationship between depth of response and PFS and OS.Log-rank test was used for univariate analysis,and COX proportional regression model was used for multivariate analysis.Results:Spearman rank correlation analysis and linear regression analysis showed that depth of response was moderately correlated with PFS and OS.According to the results of multivariate analysis,weight loss＜5%（P＜0.000 1）,depth of response（P＜0.001） were independent prognostic factors for PFS of extensive stage SCLC,and weight loss＜5%（P＜0.000 1）,ECOG PS 0~1（P=0.001 2）,depth of response（P＜0.001）,chemotherapy cycles≥4（P=0.000 2） and second line chemotherapy（P=0.006 7） were independent prognostic factors for OS of extensive stage SCLC.Conclusion:Depth of response was a prognostic factor for PFS and OS in patients with extensive stage SCLC first-line therapy patients.