| Ku80在甲状腺乳头状癌组织中的表达及其临床意义 |
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| 引用本文： | 范亚莉1,' target='_blank'>2,王娟红1,' target='_blank'>3,魏 威3,张 毓1,张莹莹1,' target='_blank'>2,李娜苗1,' target='_blank'>2,董 娅1,' target='_blank'>2,赵钰玲1,' target='_blank'>2,李建英1. Ku80在甲状腺乳头状癌组织中的表达及其临床意义[J]. 现代肿瘤医学, 2019, 0(3): 393-396. DOI: 10.3969/j.issn.1672-4992.2019.03.008 |
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| 作者姓名： | 范亚莉1 ' target='_blank'>2 王娟红1 ' target='_blank'>3 魏 威3 张 毓1 张莹莹1 ' target='_blank'>2 李娜苗1 ' target='_blank'>2 董 娅1 ' target='_blank'>2 赵钰玲1 ' target='_blank'>2 李建英1 |
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| 作者单位： | 1.西安交通大学医学院附属西安市中心医院，陕西 西安 710003;2.延安大学医学院，陕西 延安 716000;3.西安市第三医院，陕西 西安 710082 |
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| 基金项目： | National Natural Science Foundation of China(No.81372857）；国家自然科学基金资助项目（编号:81372857）；陕西省科学技术研究发展计划项目（编号:2008K09-09）；西安市科技计划项目［编号:SF09027(9),2016047SF/YX03(3)］ |
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| 摘 要： | 目的:探讨甲状腺乳头状癌组织中Ku80的表达水平及其与临床病理特征的关系。方法:收集22例甲状腺乳头状癌患者的组织蜡块，应用免疫组化检测甲状腺乳头状癌、癌旁组织中Ku80的表达，并分析Ku80表达与甲状腺乳头状癌临床病理特征的关系。结果:甲状腺乳头状癌组织中Ku80阳性表达率为63.6%，癌旁组织阳性表达率为22.7%，差异有统计学意义（P<0.05）；Ku80表达与患者的肿瘤TNM分期中T分期有关（P=0.005），与患者年龄、性别、是否有淋巴结转移、肿瘤大小、发病部位及是否有其他合并症无显著相关性（P>0.05）。结论:Ku80在甲状腺乳头状癌中高表达，并与肿瘤T分期显著相关。
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| 关 键 词： | 甲状腺乳头状癌 Ku80 免疫组化 |
Expression of Ku80 in thyroid papillary carcinoma and its clinical significance |
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| Fan Yali1,' target='_blank'>2,Wang Juanhong1,' target='_blank'>3,Wei Wei3,Zhang Yu1,Zhang Yingying1,' target='_blank'>2,Li Namiao1,' target='_blank'>2,Dong Ya1,' target='_blank'>2,Zhao Yuling1,' target='_blank'>2,Li Jianying1. Expression of Ku80 in thyroid papillary carcinoma and its clinical significance[J]. Journal of Modern Oncology, 2019, 0(3): 393-396. DOI: 10.3969/j.issn.1672-4992.2019.03.008 |
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| Authors: | Fan Yali1 ' target='_blank'>2 Wang Juanhong1 ' target='_blank'>3 Wei Wei3 Zhang Yu1 Zhang Yingying1 ' target='_blank'>2 Li Namiao1 ' target='_blank'>2 Dong Ya1 ' target='_blank'>2 Zhao Yuling1 ' target='_blank'>2 Li Jianying1 |
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| Affiliation: | 1.Xi'an Central Hospital Affiliated to Medical College of Xi'an Jiaotong University，Shaanxi Xi'an 710003，China；2.Medical College of Yan'an University，Shaanxi Yan'an 716000，China；3.Xi'an Third Hospital，Shaanxi Xi'an 710082，China. |
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| Abstract: | Objective:To investigate the expression of Ku80 in papillary thyroid carcinoma(PTC) and its relationship with clinicopathological features.Methods:Twenty-two paraffin blocks of thyroid papillary carcinoma were collected and the expression of Ku80 in papillary thyroid carcinoma and paracancerous tissues were detected by immunohistochemistry.The relationship between Ku80 expression and clinicopathological features of papillary thyroid carcinoma was analyzed.Results:The positive expression rate of Ku80 in thyroid papillary carcinoma tissue was 63.6%，while that in paracancerous tissue was 22.7%（P<0.05).The expression of Ku80 was correlated with T stage of patients（P=0.005)，while it did not related to patient's age，gender，lymph node metastasis，tumor size，location of the tumor，and other complications（P>0.05).Conclusion:Ku80 is highly expressed in papillary thyroid carcinoma and is significantly related to the T stage of the patient with papillary thyroid carcinoma. |
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| Keywords: | thyroid papillary carcinoma Ku80 immunohistochemistry |
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