鼻咽癌放疗后残存或复发灶的临床治疗进展

鼻咽癌放疗后残存或复发的原因主要有颈部转移因素、咽旁间隙侵犯因素、颅底破坏及脑神经损伤因素、放射治疗因素等。其临床治疗主要为再程放疗、化疗、挽救性手术治疗、放射性金粒198Au经软腭种植治疗、鼻咽癌的生物治疗、靶向治疗、鼻咽癌的中医治疗等。寻求减少远处复发和降低放疗相关毒性、控制联合治疗模式的急性反应以及远期毒性、提高患者生存质量是进一步研究的方向。

Residual or Recurrent Nasopharyngeal Carcinoma Following Radiotherapy: Progress of Clinical Treatment

The residual or recurrence of nasopharyngeal carcinoma is mainly caused by cervical metastasis,parapharyngeal invasion,cranial base and cranial nerve destruction and radiotherapy.The therapeutic regimens consist of repeated radiotherapy,chemotherapy,salvage surgery,soft palate implantation of radioactive 198Au,biotherapy,targeted therapy and Chinese traditional medicines.It is significant to decrease the distant recurrence and radio/chemotherapy-related toxicity,control the acute and long-term toxicity of combined regimens and further improve the life quality of patients.