Association of ovarian response with picoAMH in women undergoing controlled ovarian hyperstimulation |
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| Institution: | 1. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, TX, United States;2. Family Fertility Center, Texas Children’s Hospital, Houston, TX, United States;3. Department of Pathology, Texas Children’s Hospital, Houston, TX, United States;1. NICHE Research Group, Faculty of Computer Science, Dalhousie University, Halifax, NS, Canada;2. Department of Pathology and Laboratory Medicine, Nova Scotia Health Authority, Dalhousie University, Halifax, NS, Canada;3. Division of Neurosurgery, Dalhousie University, Halifax, NS Canada;4. Division of Endocrinology, Dalhousie University, Halifax, NS Canada;1. Department of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA;2. Applied Research and Technology, Abbott Diagnostics, Abbott Park, IL, USA;3. Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA;1. Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada;2. Alberta Precision Laboratories, Edmonton, Alberta, Canada;1. Department of Endocrinology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China;2. Department of Hematology, West China Hospital of Sichuan University, West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan, China;3. Hematology Research Laboratory, Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China;1. First Department of Pediatrics, School of Medicine, National & Kapodistrian University of Athens, “Aghia Sophia” Children''s Hospital, Athens, Greece;2. Department of Clinical Biochemistry, “Aghia Sophia” Children’s Hospital, Athens, Greece;3. IFCC Emerging Technologies Division, Emerging Technologies in Pediatric Laboratory Medicine (C-ETPLM), Milano, Italy |
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| Abstract: | ObjectiveOur study aims to evaluate the diagnostic performance of a high-sensitivity picoAnti-Müllerian Hormone (picoAMH) for predicting ovarian response in women undergoing controlled ovarian hyperstimulation and occurrence of ovarian hyperstimulation syndrome.MethodsRetrospective cohort study at a single academic fertility center including all patients with picoAMH ELISA who underwent controlled ovarian hyperstimulation. The primary outcome was the number of oocytes retrieved, and secondary outcomes included cycle cancellation and ovarian hyperstimulation syndrome. Patients were grouped into poor, normal, and hyper-responders based on number of oocytes retrieved.ResultsThe mean AMH and antral follicle count (AFC) were significantly different between normal response vs. hyper response group (p < 0.0001). Only serum AMH and not AFC was significantly increased in patients diagnosed with ovarian hyperstimulation syndrome (OHSS). For prediction of OHSS, receiver operating characteristic (ROC) analysis revealed that AMH (area under the ROC curve AUC] = 0.85) was significantly better than the AFC (AUC = 0.64). The serum AMH cut-off at sensitivity of 80% for predicting OHSS among hyper responders from ROC curve was 3.67 ng/ml. Serum AMH measured by picoAMH ELISA showed superior correlation to number of oocytes retrieved when compared to AFC in the age group over 40 years old (r2 = 0.74 and r2 = 0.4, respectively)ConclusionThis study shows great utility of picoAMH ELISA for predicting ovarian response to controlled ovarian hyperstimulation (COH). Diagnostic performance of picoAMH for prediction of OHSS is superior to the AFC in our cohort. |
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| Keywords: | Amh Pcos Ovarian hyperstimulation Antral follicle |
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