Identification and characterization of neurons with tremor-frequency activity in human globus pallidus |
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Authors: | W D Hutchison A M Lozano R R Tasker A E Lang J O Dostrovsky |
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Institution: | (1) Division of Neurosurgery, The Toronto Hospital (Western Division), Toronto, Ontario, Canada, CA;(2) Department of Surgery, The Toronto Hospital (Western Division), EW6-528, 399 Bathurst Street, Toronto, Ontario, Canada M5T 2S8; Tel.: +1 (416) 603–5800, ext. 2226, Fax: +1 (416) 603–5298, CA;(3) Division of Neurology, The Toronto Hospital (Western Division), Toronto, Ontario, Canada, CA;(4) Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada, CA |
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Abstract: | Many previous studies have demonstrated the existence of neurons with tremor-frequency activity (”tremor cells”) in the thalamus
of Parkinson’s disease (PD) patients and these neurons are presumed to play a role in the pathogenesis of tremor. Since a
major input to motor thalamus (Voa and Vop) is from the internal segment of the globus pallidus (GPi), neurons with tremor-frequency
activity in motor thalamus may receive input from neurons in GPi. The aim of this study was to quantify the characteristics
of tremor cells in human globus pallidus. In three PD patients with tremor undergoing microelectrode exploration of the globus
pallidus prior to pallidotomy, 228 neurons were sampled, and 28 (12.3%) were identified to fire at the same frequency as the
tremor. These ”tremor cells” were located in the ventral portion of GPi. Autocorrelogram analysis of the sampled spike trains
of these 28 tremor cells was carried out over sequential 10-s time segments, and autocorrelograms showing maximal oscillatory
activity were graded from 0 to 10. Average tremor cell oscillation grades ranged from 6.8 to 7.8, similar to those reported
in the MPTP-induced primate model of parkinsonism. The average tremor cell oscillation grade varied between patients, as did
the clinical measures of tremor severity. Tremor cells had oscillations in spike discharges at the same average frequency
(4.2–5.2 Hz) as the patient’s tremor determined from the electromyogram and accelerometry records of one or more limbs (4.0–5.4
Hz), and the individual values were correlated (r
2=0.73) over the total range (3.7–5.6 Hz). The results of this study demonstrate the presence of neurons with 4–6 Hz tremor-frequency
activity in GPi, supporting a role of the globus pallidus in the production of rest tremor in PD patients.
Received: 27 February 1996 / Accepted: 18 October 1996 |
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Keywords: | Tremor cells Parkinson’ s disease Rest tremor Human globus pallidus |
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