R497K polymorphism in epidermal growth factor receptor gene is associated with the risk of acute coronary syndrome |
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| Authors: | Lin-Bo Gao Bin Zhou Lin Zhang Ye-Sheng Wei Yan-Yun Wang Wei-Bo Liang Mei-Li Lv Xin-Min Pan Yu-Cheng Chen Li Rao |
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| Affiliation: | (1) Department of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, 610041 Chengdu Sichuan, PR, China;(2) Laboratory of Molecular Translational Medicine, West China Second University Hospital, Sichuan University, 610041 Chengdu Sichuan, PR, China;(3) Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, 610041 Chengdu Sichuan, PR, China;(4) Department of Forensic Pathology, West China School of Preclinical and Forensic Medicine, Sichuan University, 610041 Chengdu Sichuan, PR, China;(5) Department of Cardiology, West China Hospital of Sichuan University, 610041 Chengdu Sichuan, PR, China |
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| Abstract: | ![]()
Background Previous studies suggested that genetic polymorphisms in the epidermal growth factor receptor (EGFR) gene had been implicated in the susceptibility to some tumors and inflammatory diseases. EGFR has been recently implicated in vascular pathophysiological processes associated with excessive remodeling and atherosclerosis. Acute coronary syndrome (ACS) is a clinical manifestation of preceding atherosclerosis. Our purpose was to investigate the association of the EGFR polymorphism with the risk of ACS. In this context, we analyzed the HER-1 R497K and EGFR intron 1 (CA)n repeat polymorphisms in 191 patients with ACS and 210 age- and sex-matched controls in a Chinese population, using a polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) strategy and direct sequencing. |
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