糖皮质激素的使用对中心性浆液性脉络膜视网膜病变发病的影响

目的:探讨糖皮质激素的使用是否是中心性浆液性脉络膜视网膜病变(central serous chorioretinopathy,CSCR)发病的危险因子。方法:前瞻性病例对照研究。对连续的100例急性CSCR患者就糖皮质激素的使用状况进行问卷调查。从同期就诊的非CSCR的门诊患者中根据年龄和性别选择病例与之匹配,以建立对照组,并进行相同的问卷回答。结果:在100例CSCR患者中,10例(10%)有激素使用史,男4例,女6例。而100例对照患者中仅有3例(3%)有激素使用史,男2例,女1例。两组之间有显著性差异。结论:通过前瞻性的病例对照研究,我们发现使用糖皮质激素是CSCR发病的危险因子。

Effect of glucocorticoids on the onset of central serous chorioretinopathy

AIM:To evaluate whether exposure to glucocorticoids was a risk factor for the onset of central serous chorio-retinopathy (CSCR). ·METHODS:One hundred consecutive patients with acute CSCR were asked to answer a specific questionnaire regarding the use of glucocorticoids. An age and sex matched control group was also recruited. The control group consisted of patients attending the outpatient clinic for a fundus disease other than CSCR,who were asked to answer the same questionnaire. ·RESULTS:Use of glucocorticoids was recorded in 10 of 100 patients(10%)with CSCR;4 of them were men ,and 6 women. In the control group,use of glucocorticoids was recorded in 3 of 100 patients(3%),2 men and 1 woman. The difference between the two groups was statistically significant (χ2=39.66,P<0.05). ·CONCLUSION:In this prospective case-control study,we found that glucocorticoid use presents a risk factor for the onset of CSCR.