| 羟乙基淀粉130/0.4急性高容量血液稀释对血液流变学和凝血功能的影响 |
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| 引用本文： | 秦秦,杨瑞,龙卫红,白宁,张昕.羟乙基淀粉130/0.4急性高容量血液稀释对血液流变学和凝血功能的影响[J].临床麻醉学杂志,2009,25(3). |
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| 作者姓名： | 秦秦 杨瑞 龙卫红 白宁 张昕 |
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| 作者单位： | 陕西省人民医院麻醉科,西安市,710068 |
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| 摘 要： | 目的 观察6%羟乙基淀粉(HES)130/0.4急性高容量血液稀释(AHH)对高凝状态的恶件肿瘤患者血液流变学和凝血功能的影响.方法 择期在全麻下行胃、肠癌根治术伴高凝状态患者40例,随机分为两组,每组20例.全麻插管后H组输注HES 130/0.4,R组输注复方乳酸钠,均以15～20 ml/kg(25～35 ml/min)输注.分别于AHH前(T0)、AHH结束后即刻(T1)、AHH结束后60 min(T2)和手术结束时(T3)采静脉血检测血液流变学和凝血功能.结果 H组AHH后各时点全血高切粘度、低切粘度、血浆粘度、血细胞比容(Hct)及血小板聚集率明显低于T0时(P<0.05);H组AHH后各时点Hb、血小板计数(Pit)低于R组(P<0.05);H组AHH后各时点部分活化凝血活酶时间(APTT)较R组明显延长(P<0.05),但两组均在正常范围;H组纤维蛋白原(FIB)降低更为显著(P<0.05).结论 HES 130/0.4 AHH用于恶性肿瘤患者能改善血液流变学,改善肿瘤患者的高凝状态,但对凝血功能的影响较小.
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| 关 键 词： | 高凝状态 血液稀释 血液流变学 凝血功能 |
Influence of HES130/0.4 acute hypervolemic hemodilution on hemorheology and blood coagulation of malignant tumor patients |
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| QIN Qin,YANG Rui,LONG Wei-hong,et al..Influence of HES130/0.4 acute hypervolemic hemodilution on hemorheology and blood coagulation of malignant tumor patients[J].The Journal of Clinical Anesthesiology,2009,25(3). |
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| Authors: | QIN Qin YANG Rui LONG Wei-hong |
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| Institution: | QIN Qin,YANG Rui,LONG Wei-hong,et al.Department of Anesthesiology,People's Hospital of Shannxi Province,Xi'an 710068,China |
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| Abstract: | Objective To study the influence of acute hypervolemic hemodilution with hydroxyethyl Starch(HES)130/0.4 on hemorheology and blood coagulation of malignant tumor patients.Methods Fourty patients with hypercoagulability undergoing radical operation of gastroenteral cancers were divided into two groups with 20 cases each.Patients in group H were infused HES 15-20ml/kg(25-35ml/min),and those in group R lactated Ringers solution instead of HES.The vein blood was taken before AHH(T0),at completion of infusion(T1... |
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| Keywords: | Hypercoagulability Hemodilution Hemorheology Blood coagulation |
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