脑垂体移植实验研究——Ⅳ.兔脑垂体移植后生化指标的改变

本文以正常兔子为对照,分析了垂体切除及垂体移植后兔血中8项生化指标的改变。发现垂体全切组的兔子处于极显著的高 Na、高 Cl、高 UN 状态(P<0.01),垂体切除后再移植的三组,Na、Cl、UN 也明显高于对照组(P<0.05)。以上四组的 TP、ALb 均较正常组低(P<0.05)。垂体未切除而额外移植垂体的两组,上述各指标均无明显变化。六个组的血糖均普遍偏高,而 K、Ca 无显著改变。以上结果显示了实验动物体内水、电解质平衡的失调和生化代谢的变化,提示临床和实验中在植入的垂体功能恢复前,应注意营养饮食、调节水和电解质平衡、监测糖、蛋白代谢指标。由此可间接了解各生物体内垂体损伤及术后植入垂体功能重建的程度。

Biochemical Changes Following Pituitary Grafts in Rabbits

The serum concentrations of eight biochemical compounds in experi- mental pituitary transplanted rabbits were measured.Normal rabbits were used as control group.The results showed remarkably high level of Na,Cl,UN in total hypophysectomized rabbits (P<0.01).The levels of Na,Cl,UN in other three gro- ups which pituitary graft transplanted after hypophysectomy were also significantly higher than control group (P<0.05).Levels of TP,Alb in all four groups were lower than the n0rmal control (P<0.05). Comparing with the control group there was no definite defference in those eight compounds for the two groups which extra-grafts were implanted without hypophy- sectomy.In all six groups mentioned.above,the glucose content was alightly high- er than the control group,but there was no obvious difference in K or Ca concen- tration. These results showed that water-electrolytes imbalance and biochemical metabolism abnormalities were existed in the experimental animals.The nutritional support, water-electrolyte balance maintenance,glucose-protein metabolism monitoring were meaningful before the restoration of pituitary graft function.