大肠癌患者血清HSP60和MMP-9的变化及其意义

目的探讨大肠癌患者围手术期血清热休克蛋白60（HSP60）和基质金属蛋白酶-9（MMP-9）水平的变化及其临床意义。方法采用ELISA法分别测定76例大肠癌患者手术前后血清HSP60和MMP-9的含量，并与大肠良性疾病组和健康对照组比较分析。结果大肠癌组治疗前血清HSP60和MMP-9均增高，与大肠良性疾病组和健康对照组比较有显著性差异（P〈0．01）；且与淋巴结转移和肿瘤临床Duke’s分期呈明显相关性。行根治性手术组术后血清HSP60和MMP-9均有显著性降低（P〈0．05），而姑息性手术组血清HSP60和MMP-9则无显著性降低（P〉0．05）。结论大肠癌患者血清HSP60和MMP-9的水平明显升高，检测大肠癌患者血清HSP60和MMP-9的变化，有助于估计患者的病情。

Changes and clinical significance of serum HSP60 and MMP-9 in patients with colorectal cancer

Objective To investigate the changes of levels of serum HSP60 （heat shock protein 60） and MMP-9 （matrix metalloproteinases-9） in patients with colorectal cancer befor and after operation,. Methods The contents of serum HSP60 and MMP-9 in 76 patients with colorectal cancer were detected by ELISA respectively befor and after opreration and compared them with that of colorectal benign group and health controls. Results The contents of serum HSP60 and MMP- 9 in the patients with colorectal cancer befor operation were significantly higher than that in colorectal benign group and health control group （P〈0.01）.There was significant correlation between the contents with lymph node metastasis and clinical stage （Duke＇s） （P〈0.05）. The contents of HSP60 and MMP-9 were significantly decreased in the patients with colorectal cancer after radical operation （P〈0.05）.But there was not significantly decrease of the contents of HSP60 and MMP-9 in patients with colorectal cancer after palliative resection （P〉0.05）. Conclusion The contents of HSP60 and MMP-9 are increased in patients with colorectal cancer and determination of the contents of serum HSP60 and MMP-9 may be an important index for evalution of invasion,metatasis,efficiacy and progrosis for the patients with colorectal cancer.