| CD38在慢性B淋巴细胞白血病细胞上表达的临床意义 |
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| 引用本文： | 张文艺,王冬侠,曹军,姜琪. CD38在慢性B淋巴细胞白血病细胞上表达的临床意义[J]. 标记免疫分析与临床, 2009, 16(3): 136-139 |
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| 作者姓名： | 张文艺 王冬侠 曹军 姜琪 |
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| 作者单位： | 中国中医血液专病治疗中心,河北廊坊市中医院临床检验中心,河北,廊坊,065000 |
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| 摘 要： | 为探讨CD38在慢性B淋巴细胞白血病（B-CLL）细胞上表达的临床意义,用流式细胞仪检测了78例慢性B淋巴细胞白血病细胞上CD38的表达。结果显示,CD38的表达与患者年龄、骨髓中白血病细胞比例、外周血白细胞数目、血红蛋白含量、血小板数和脾肿大无关（P〉0.05）,而与Binet分期（C期）、外周血白血病细胞比例、淋巴结肿大和肝肿大有关（P值分别为0.017、0.037、0.039、0.038）,并有明显缩短的生存期（P=0.032）。结论：CD38高表达是B-CLL患者预后差的一个可靠指标。
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| 关 键 词： | 慢性B淋巴细胞白血病 CD38 流式细胞仪 预后 |
Clinical Significance of CD38 Expression in Chronic B Lymphocytic Leukemia |
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| ZHANG Wen-yi,WANG Dong-xia,CAO Jun,JIANG Qi. Clinical Significance of CD38 Expression in Chronic B Lymphocytic Leukemia[J]. Labeled Immunoassays and Clinical Medicine, 2009, 16(3): 136-139 |
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| Authors: | ZHANG Wen-yi WANG Dong-xia CAO Jun JIANG Qi |
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| Affiliation: | ZHANG Wen-yi,WANG Dong-xia,CAO Jun,JIANG Qi(Clinical Laboratory Center,the Hospital of Traditional Chinese Medicine of Langfang,Langfang 065000,China) |
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| Abstract: | To explore the clinical significance of CD38 expression in chronic B lymphocytic leukemia(B-CLL),the expression of CD38 in 78 cases with B-CLL were analyzed by flow cytometry.The results showed that CD38 expressions in chronic B lymphocytic leukemia were significantly related with Binet stage,B-CLL cells in peripheral blood,lymphadenopathy and hepatomegaly.The patients with CD38 over-expression showed a shorter overall survival.The CD38 expression could be as a poor prognostic indicator in B-CLL. |
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| Keywords: | CD38 |
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