复方倍他米松注射联合甘草锌颗粒口服治疗中重度斑秃疗效分析

目的:探究复方倍他米松联合甘草锌颗粒治疗中重度斑秃的临床疗效。方法:选取2016年4月-2018年2月笔者医院收治的80例斑秃患者,随机分为观察组(n=40)与对照组(n=40),按照斑秃严重程度将观察组分为中度组(n=22)及重度组(n=18),观察组给予复方倍他米松局部注射与甘草锌颗粒口服联合治疗;对照组仅给予复方倍他米松局部注射治疗。以3周为1个疗程,连续治疗3个疗程,观察治疗1、2、3个疗程后两组患者的临床疗效、不良反应发生率及复发率。结果:治疗3个疗程后,观察组总有效率42.50%,明显高于对照组的20.00%(P<0.05);观察组总有效率42.50%明显高于本组治疗1个疗程后15.00%(P<0.05),其中中度组总有效率59.09%,高于本组治疗1个疗程(22.72%)及2个疗程后的有效率(27.27%)(P<0.05);中度组总有效率59.09%,高于重度组22.22%(P<0.05);中度组转阴率68.18%明显高于重度组44.44%(P<0.05)。治疗1、2、3个疗程后观察组总不良反应发生率7.50%、17.50%、25.00%,与对照组12.50%、15.00%、22.50%比较,均无显著性差异(P>0.05)。治疗结束后6个月,观察组复发率17.50%与对照组32.50%比较,无显著性差异(P>0.05)。结论:对中、重度斑秃患者采用复方倍他米松注射法联合甘草锌颗粒口服治疗,具有较好的临床治疗效果,尤其对中度斑秃患者治疗有效率高。

Effect of Compound Betamethasone Injection Combined with Oral of Licorzinc Granules on Moderate and Severe Alopecia Areata

Objective To investigate the effect of compound betamethasone injection combined with licorzinc granules on moderate and severe alopecia areata.Methods 80 patients with alopecia areata admitted to our hospital between April 2016 and February 2018 were selected,and randomly divided into the observation group (n=40) and the control group (n=40).The observation group was further divided into two groups according to the severity degree,namely moderate group (n=21) and severe group (n=19).The control group received the compound betamethasone injection,based on this,the observation group received the licorzinc granules.All patients were treated for three courses,with three weeks as one course.The clinical efficacy,incidence of adverse reactions and recurrence rate of two groups after 1,2 and 3 treatment courses were observed.Results The total effective rate of the observation group at the post-treatment 3 courses was higher than that of the control group (42.50% vs 27.50%,P<0.05).The total effective rate of the observation group at the post-treatment 3 courses was higher than that at post-treatment 1 course(42.50% vs 15.00%,P<0.05).The total effective rate of the moderate group at the post-treatment 3 courses was higher than that at post-treatment 1 course and 2 courses (59.09% vs 22.72%,27.27%,P<0.05).The total effective rate of moderate group was significantly higher than that of severe group at the post-treatment 3 courses (59.09% vs 22.22%,P<0.05).The negative conversion rate of moderate group was significantly higher than that of severe group at the post-treatment 3 courses (68.18% vs 44.44%,P<0.05).The incidence of total adverse reactions showed no significant difference between the observation group and the control group at post-treatment 1 course,2 courses and 3 courses (7.50% vs 12.50%,17.50% vs 15.00%,25.00% vs 22.50%,P>0.05).The recurrence rate between the observation group and the control group showed no significant difference after 6mon of treatment(17.50% vs 32.50%,P>0.05).Conclusion The application of the compound betamethasone injection combined with licorzinc granules presents good clinical efficacy for moderate and severe alopecia areata patients,especially for moderate alopecia areata patients.The combined treatment in this study presents a quite limited total efficacy,so further studies of other combined treatment methods are also required.