普萘洛尔联合其他治疗措施治疗婴幼儿血管瘤有效率的网状Meta分析

目的:采用网状Meta分析方法,将普萘洛尔联合其他治疗与各对照治疗措施进行对比。方法:以“普萘洛尔”,“血管瘤”为关键词检索CNKI、VIP、万方数据;以“propranolol”“hemangioma”为关键词检索Cochrane Library、Embase、pubmed。检索期限为建库至2019年6月1日。采用STATA14.0软件Network程序包进行数据分析。结果:共纳入18篇文献,涉及8项治疗措施,共纳入1469例血管瘤患者。网状Meta分析结果显示:4种联合治疗方式与单纯口服普萘洛尔相比疗效均优于单纯口服普萘洛尔治疗。普萘洛尔联合注射平阳霉素、普萘洛尔联合外用噻吗洛尔、普萘洛尔联合敷贴器的有效率均优于对应的注射平阳霉素、外用噻吗洛尔及敷贴器。各治疗措施的有效性排序为:普萘洛尔联合敷贴器>普萘洛尔联合外用噻吗洛尔>普萘洛尔联合口服糖皮质激素>普萘洛尔联合注射平阳霉素>敷贴器照射>外用噻吗洛尔>口服普萘洛尔>注射平阳霉素。结论:对于婴幼儿血管瘤的治疗,普萘洛尔联合治疗措施疗效均优于单纯的口服普萘洛尔治疗,其中普萘洛尔联合敷贴器的疗效最佳。

Efficient of Propranolol Combined with Other Therapy in the Treatment of Infantile Hemangiomas:A Network Meta-analysis

Objective To compare propranolol combined with other treatments and various control treatments by network metaanalysis.Methods CNKI,VIP,Wanfang data,Cochrane Library,Embase and pubmed were searched for by“propranolol”and“hemangioma”.The search period is 2019-06-01.Data analysis was performed using the STATA14.0 network package.Results A total of 18 articles were included,involving 8 treatments,involving 1469 patients with hemangioma.The results of network meta-analysis showed that the four combined treatments were superior to oral propranolol alone.The effective rate of propranolol combined with pingyangmycin,propranolol combined with topical timolol and propranolol combined with applicator was better than the corresponding injection of pingyangmycin,topical timolol,and application Sticker.The effectiveness of each treatment was ranked as follows:propranolol combined applicator>propranolol combined with topical timolol>propranolol combined with oral glucocorticoids>propranolol combined with pingyangmycin>application Patch irradiation>topical timolol>propranolol>injection of pingyangmycin.Conclusion For the treatment of infantile hemangiomas,the effi cacy of propranolol combined therapy is better than that of oral propranolol.Among them,propranolol combined with applicator is the best.