泛发性脓疱型银屑病35例临床分析

目的分析GPP的临床特征及不同治疗方法的疗效。方法对35例住院GPP患者病例资料、临床特点和治疗经过进行回顾性分析。A）甲氨喋呤10～15mg静脉滴注每周1次;b）激素（用量相当于泼尼松量0.6～1.0mg/kg/d）＋雷公藤多甙30～60mg/d;c）激素（同B）＋泰尔丝30～40mg/d;d）激素（同B）＋泰尔丝30～40mg/d＋雷公藤30～60mg/d各种药物剂量随皮损变化逐步撤减。结果a、b、c和d疗法有效率分别为75%、80%、72%和89%。上呼吸道感染和药物是发病主要诱因。结论对于重症GPP应采用联合治疗方案。

Clinical analysis of 35 patients with generalized pustulosa psoriasis

Objective To analyze the clinical features of generalized pustular psoriasis（GPP） and the efficiency of different treatments.Methods The 35 GPP cases were treated with four therapies：a）methotrexatum 10～15mg once per week;b）glucocorticoid 0.6～1.0mg/kg.d plus Leigongteng（a herbal drug） 30～60mg;c）isotretinoin capsules 30～40mg/d;d） glucocorticoid plus isotretinoin capsules plus Leigongteng 30～60mg/d.The results were analyzed.Results Upper respiratory infections and use of drugs were the main triggering factors.The effective rates of a,b,c and d were 75%,80%,72% and 89%.Conclusion Severe GPP should be treated with combination therapy.