炎琥宁联合更昔洛韦治疗小儿轮状病毒感染性腹泻的临床疗效

目的：观察炎琥宁联合更昔洛韦治疗小儿轮状病毒感染性腹泻的疗效。方法选取2010年5月-2013年12月延安市人民医院确诊的小儿轮状病毒感染性腹泻患儿235例，随机分为治疗组（120例）和对照组（115例）。对照组在常规治疗基础上静脉滴注更昔洛韦注射液，5 mg/（kg·d）加入5%葡萄糖注射液150 mL，15滴/min，1次/d。治疗组静脉滴注炎琥宁注射液，10 mg/（kg·d）加入250 mL葡萄糖注射液中，1次/d；其他治疗同对照组。两组患者均持续治疗5 d。治疗结束后比较两组患儿临床治疗总有效率、症状消失时间、人轮状病毒抗原（RV-Ag）转阴率及不良反应情况。结果治疗后，治疗组和对照组的总有效率分别为91.7%、71.3%，两组比较差异有统计学意义（P＜0.05）。治疗组体温恢复时间、呕吐消失时间、腹泻改善时间、住院时间均明显短于对照组，两组比较差异有统计学意义（P＜0.05）。治疗3 d后，治疗组患儿大便RV-Ag转阴率为85.8%，对照组转阴率为71.3%，两组比较差异有统计学意义（P＜0.05）；治疗5 d后，治疗组转阴率为100.0%，对照组转阴率为91.3%，两组比较差异有统计学意义（P＜0.05）。两组均未发生严重不良反应。结论炎琥宁联合更昔洛韦治疗小儿轮状病毒感染性腹泻有较好的临床疗效，不良反应轻微，值得临床推广应用。

Clinical efficacy of Yanhuning combined with ganciclovir in treatment of infantile rotavirus infection diarrhea

Objective To explore the curative effect of Yanhuning combined with ganciclovir in the treatment of infantile rotavirus infection diarrhea. Methods Patients （235 cases） with rotavirus infection diarrhea for the treatment in the People’s Hospital of Yan’an City from May 2010 to December 2013 were randomly divided into treatment （120 cases） and control （115 cases） groups. On the basis of conventional treatment, the patients in the control group were treated with Ganciclovir Injection 5 mg/（kg·d） by adding into 5% Glucose Injection 150 mL, 15 drops/min, once daily. The patients in the treatment group were treated with Yanhuning Injection 10 mg/（kg·d） by adding in Glucose Injection 250 mL, once daily, and other treatment was the same as the control group. The patients in both groups were treated for 5 d. After treatment, the clinical effective rate, symptoms disappearing time, RV-Ag overcast rate, and adverse reaction in two groups were compared.Results After treatment, the efficacies on the patients in the treatment and control groups were 91.7% and 71.3%, with significant difference between the two groups （P 〈 0.05）. The body temperature recovery time, vomiting disappearing time, diarrhea improving time, and time in the hospital of the treatment group were significantly shorter than those in the control group, and there was the significant difference between the two groups （P 〈 0.05）. After 3 d treatment, the RV-Ag overcast rates in the treatment and control groups were 85.8% and 71.3%, with significant difference between the two groups （P 〈 0.05）. After 5 d treatment, the RV-Ag overcast rate in the treatment and control groups were 100.0% and 91.3%, with significant difference between the two groups （P 〈 0.05）. There was no serious adverse reaction in the two groups. Conclusion Yanhuning combined with ganciclovir has a good clinical efficacy in the treatment of infantile rotavirus infection diarrhea with slight adverse reactions, which is worthy of clinical applica