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| 淋巴结病理学检查在药物安全性评价中的特点和意义 | |
| 引用本文： | 刘兆华,刘峰,武传涛,刘兆平. 淋巴结病理学检查在药物安全性评价中的特点和意义[J]. 中国药理学与毒理学杂志, 2011, 25(2): 216-219. DOI: 10.3867/j.issn.1000-3002.2011.02.017 |
| 作者姓名： | 刘兆华 刘峰 武传涛 刘兆平 |
| 作者单位： | 1. 山东大学新药评价中心 2. 胜利油田中心医院妇产科,山东,济南,250012 |
| 基金项目： | 国家"重大新药创制"科技重大专项，山东大学实验室软件建设项目 |
| 摘 要： | 淋巴结(LN)是重要的外周免疫器官,免疫应答发生的场所。LN形态结构的改变可敏感提示药物免疫毒性的有无,表明LN毒性病理学评价是免疫毒性筛选的有力手段。本文综述了LN复杂的生理结构和毒性病理学变化特点,并阐述了LN病理检查在药物安全性评价中的作用和意义。 |
| 关 键 词： | 免疫 毒性作用 淋巴结 药物评价 病理学 |
| 收稿时间： | 2010-08-30 |
Characteristics and significance of pathological examination lymph nodes in drug safety evaluation |
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| LIU Zhao-hua,LIU Feng,WU Chuan-tao,LIU Zhao-ping. Characteristics and significance of pathological examination lymph nodes in drug safety evaluation[J]. Chinese Journal of Pharmacology and Toxicology, 2011, 25(2): 216-219. DOI: 10.3867/j.issn.1000-3002.2011.02.017 | |
| Authors: | LIU Zhao-hua LIU Feng WU Chuan-tao LIU Zhao-ping |
| Affiliation: | LIU Zhao-hua1,LIU Feng2,WU Chuan-tao1,LIU Zhao-ping1(1.Center for New Drugs Evaluation,Shandong University,2.Obstertics and Gynaecology Department,Central Hospital of Shengli Oil Field,Jinan 250012,China) |
| Abstract: | Lymph nodes (LN), an important peripheral lymphoid organ, is the site for mounting immune response. Morphologic changes of LNs may predict accurately whether the test chemicals are potentially immunotoxic or not, which indicates that adequate pathological examination is a potent tool for immunotoxicity screening. The article reviews the complex and unique structure, function of normal LNs, their characteristics and significance of pathological examination in drug safety evaluation. |
| Keywords: | immunity toxic actions lymph nodes drug evaluation pathology |
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