| 胃肠道腺癌组织中COX-2的表达及意义 |
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| 引用本文： | 高秀江,李淑静,朱振龙,何春年. 胃肠道腺癌组织中COX-2的表达及意义[J]. 中国煤炭工业医学杂志, 2011, 14(10): 1428-1430 |
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| 作者姓名： | 高秀江 李淑静 朱振龙 何春年 |
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| 作者单位： | 1. 河北医科大学第一医院,河北省石家庄市,050051
2. 河北省人民医院病理科 |
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| 摘 要： | 目的探讨COX-2在胃肠道腺癌组织中的表达及其临床意义。方法本课题以经病理证，实的胃肠道腺癌组织37例为研究组，以其胃肠道腺癌淋巴结转移组织37例和正常胃肠道黏膜组织37例为对照组。采用链霉素-生物素（S-P）免疫组化技术，测定胃肠道腺癌、正常胃肠道黏膜、淋巴结转移的癌组织中COX-2的表达。采用Wilcoxon秩和检验进行组间比较。结果胃肠道腺癌、胃肠道腺癌淋巴结转移组织中COX-2蛋白阳性表达率均明显高于正常胃肠道黏膜组织，差异具有统计学意义；胃肠道腺癌组织中COX-2蛋白阳性表达率略高于胃肠道腺癌淋巴结转移组，但二者之间差异无统计学意义。结论COX-2在胃肠道腺癌及其淋巴结转移癌的组织中表达水平高于正常胃肠道黏膜，其表达水平与肿瘤的发生、发展、浸润、转移相关，检测上述标志物有一定的临床及病理意义。
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| 关 键 词： | 胃肠道腺癌 免疫组化 环氧化酶 |
EXPRESSION OF THE COX- 2 IN GASTROINTESTINAL ADENOCARCIOMA TISSUE AND ITS CLINICAL SIGNIFICANCE |
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| Gao Xiujiang,Li Shujing,Zhu Zhenlong,et al.. EXPRESSION OF THE COX- 2 IN GASTROINTESTINAL ADENOCARCIOMA TISSUE AND ITS CLINICAL SIGNIFICANCE[J]. Chinese Journal of Coal Industry Medicine, 2011, 14(10): 1428-1430 |
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| Authors: | Gao Xiujiang Li Shujing Zhu Zhenlong et al. |
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| Affiliation: | Gao Xiujiang,Li Shujing,Zhu Zhenlong,et al.Department of Pathology,The First Affiliated Hospital of Hebei Medical University,Shijiazhuang 050051,China |
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| Abstract: | Objective To investigate the expression of cyclooxygenase-2 in gastrointestinal adenocarcioma tissue and its possible clinical significance.Methods The study group was pathologically proved gastrointestinal adenocarcioma and the control group were normal gastrointestinal mucous membrane and metastasis lymph node of gastrointestinal adenocarcioma.There were 37 cases in each group.Immunohistochemistry SP method was used to examine the expression of cyclooxygenase-2 in gastrointestinal adenocarcioma,normal gas... |
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| Keywords: | gastrointestinal adenocarcioma immunohistochemistry cyclooxygenase-2 |
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