帕罗西汀联合认知行为疗法治疗抑郁症的临床研究

目的探讨帕罗西汀联合认知行为疗法治疗抑郁症的临床疗效。方法选取82例抑郁症患者,将其随机分为观察组和对照组,每组各41例。对照组患者每日口服帕罗西汀片20 mg;观察组患者在每日给予帕罗西汀片20 mg的基础上进行认知行为治疗,每次30 m in,每周2次,两组均连续治疗8周。分别于治疗前、治疗第4周末、治疗第8周末采用汉密尔顿抑郁量表（HAMD）评定抑郁症状,比较两组间的差异以及临床疗效。结果两组患者治疗第4周末、第8周末的HAMD评分均较治疗前明显减轻（P〈0.05,P〈0.01）,并且以观察组的下降幅度相对较显著,组间比较,差异具有统计学意义（P〈0.05）。观察组的有效率为92.7%,对照组有效率为73.2%,差异有统计学意义（P〈0.05）。结论帕罗西汀联合认知行为疗法能有效改善抑郁症患者的抑郁状态,提高疗效。

Clinical Study of Paroxetine with Cognitive-Behavioral Therapy on Depression

Objective To observe the clinical effect of paroxetine combined with the cognitive-behavioral therapy on depression.Methods Eighty two patients with depression were randomly divided into observation group and control group(each 41 cases).The patients in control group received paroxetine 20 mg/d,while the patients in observation group received paroxetine 20 mg/d and the cognitive-behavioral therapy,once every 30 minutes,twice a week.The treatment period of both groups was 8 weeks.Before the treatment and at ...