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Positron emission tomography of murine liver metastases and the effects of treatment by combretastatin A-4
Authors:Sha Zhao  James V. Moore  Michael L. Waller  Alan T. McGown  John A. Hadfield  George R Pettit  David L. Hastings
Affiliation:(1) North West Medical Physics, Christie Hospital (NHS) Trust, Manchester, UK, GB;(2) Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK, GB;(3) Cancer Research Institute, Arizona State University, USA, US
Abstract:
. There are major potential advantages in non-invasive measurement of preclinical tumour biology and therapeutic response in clinically relevant, internal body sites, notably the ability to follow outcome in individual animals rather than averaging results from groups. We have exploited positron emission tomography (PET) to determine the feasibility of detecting liver metastases in B6D2F1 mice using fluorine-18 fluorodeoxyglucose ([18F]FDG) both before and after treatment by the novel cytotoxic agent, combretastatin A-4. The normal distribution of [18F]FDG in the absence of disease was characterised, with the clear delineation of the brain, the heart and the urinary bladder in all studies. In untreated mice with liver metastases, a strong correlation (r 2 = 0.98) was found between the quantitative estimates of [18F]FDG uptake obtained by analysis of PET images, and those obtained from ex vivo assay of liver plus metastases excised immediately after imaging. In this first series, the effective limit of resolution was in livers containing a number of small metastases (range 8–14) with a single volume equivalent of approximately 200 mm3. PET image analysis was concordant with histological measurements in showing that single intraperitoneal doses of combretastatin A-4 resulted in an average 30% volume destruction of metastatic mass by 24 h following administration. Received 1 August and in revised form 26 October 1998
Keywords:: Positron emission tomography  Fluorodeoxyglucose  Liver  Metastasis  Combretastatin A-4
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