手足口病患儿血浆C反应蛋白及外周血白细胞变化特点

目的 探讨手足口病患儿血浆C反应蛋白(CRP)及外周血白细胞(WBC)变化特点.方法 回顾性分析29例手足口病患儿临床资料.按年龄把小于或等于1岁的患儿分为第1组,>1岁的患儿为第2组.分别记录两组患儿入院时血浆CRP及外周血WBC,并进行统计学分析.结果 29例中男孩18例,女孩11例,男∶女为1.8∶1.0.≤1岁患儿11例,占37.9%,>1岁患儿18例,占62.1%.第2组患儿血清CRP浓度[(21.666 7±15.695 6)mg/L]较第1组高[(10.090 9±10.329 1)mg/L],差异有统计学意义(P=0.039 1).而两组的外周血WBC差异无统计学意义(P=0.113 8).结论 男孩患手足口病比例较高,年龄大的儿童比年龄小的儿童容易患手足口病,且血清CRP浓度也较高,但两组患儿外周血WBC无明显差别.

Change characteristics of C-reactive protein and peripheral white blood cells in HFMD patients

Objective To study the change characteristics of C-reactive protein（CRP） and peripheral white blood cells（WBC） in the patients with hand,foot and mouth disease（HFMD）.Methods The clinical data of 29 hospitalized patients with mild HFMD from June 2010 to September 2010 were retrospectively analyzed.The patients were divided into two groups,the first group（age ≤1 year old） and the second group（age 1 year old）.Plasma CRP and peripheral WPC were tested in all patients and statistically analyzed.Results There were 18 males and 11 females,the ratio of male to female was 1.8∶1.0.There were 11 cases（37.9%） in the first group and 18 cases（62.1%） in the second group.The CRP concentration in the second group was significantly higher than that of the first group[（21.666 7±15.695 6）mg/L vs.（10.090 9±10.329 1）mg/L,P=0.039 1],showing statistical difference（P=0.039 1）.But there was no statistical difference in the WBC counts between the two groups[（10.4182±2.9866）×109 vs.（8.833 3±2.224 5）×109,P=0.113 8].Conclusion The proportion of HFMD in boys is higher.Older children are easier to suffer from HFMD than younger children with higher CRP concentration.Peripheral WBC counts have no obvious difference between the children age ≤1 year old and age 1 year old.