乙型肝炎病毒前S1抗原与乙型肝炎病毒e抗原及肝功能指标之间的关系研究

目的通过分析乙型肝炎病毒（HBV）前S1抗原与乙型肝炎病毒e抗原（HBeAg）及肝功能指标谷丙转氨酶之间的关系，探讨HBV前S1抗原在病毒复制中的意义及与肝功能损害程度的相关性。方法对2012年5月-7月住院及门诊的HBV表面抗原阳性的慢性乙型肝炎患者血清标本310例进行检测，HBV前sI抗原采用酶联免疫吸附试验检测；HBeAg采用化学发光法检测；谷丙转氨酶采用酶学速率法检测。结果①HBeAg阳性组前S1抗原检出率高；②HBV前S1抗原与具有病毒活动性复制意义的指标HBeAg有高度的相关性；③谷丙转氨酶水平增高时前S1抗原阳性率增高。结论HBV前S1抗原检测结果可以较好地反映HBV的复制及慢性肝炎的活动情况。

Study on the Relationship among Hepatitis B Virus PreS1, Human Hepatitis B e Antigen and Liver Fuction in Serum of Hepatitis B Patients

Objective To evaluate the relationship between hepatitis B virus （HBV） preS1 antigen and the virus replication index human hepatitis B e antigen （HBeAg） and liver function. Methods A total of 310 cases of serum samples from patients with chronic HBV treated in our hospital between May and July 2012 were examined and studied. HBV preSl antigen was detected by ELISA; HBeAg was detected by the Architect i2000 system; and alanine transaminase （ALT） was detected by kinetic method. Results The detection rate of HBV preS1 antigen was higher in HBeAg positive group. HBV preS1 antigen was correlated with HBeAg which was an index of virus replication. HBV preS1 antigen was correlated with ALT levels. Conclusion The levels of HBV preS1 antigen may reflect the replication of HBV and the reactiveness condition of chronic hepatitis..