电针配合盐酸氨基葡萄糖治疗膝骨关节炎的临床研究

目的观察电针配合口服盐酸氨基葡萄糖胶囊治疗膝骨关节炎的临床疗效，并对比单纯电针和单纯VI服盐酸氨基葡萄糖胶囊治疗的疗效差异。方法将2006年3月-2012年12月诊治的168例膝骨关节炎患者随机分为3组，电针联合口服盐酸氨基葡萄糖胶囊治疗为治疗组（58例），单纯电针治疗为对照组A（57例），单纯口服盐酸氨基葡萄糖胶囊为对照组B（53例），疗程均为6周。分别于治疗前和治疗后3、6周末及治疗结束后6个月末，采用膝关节国际骨关节炎Lequesne评分标准指数评定各组分值和总有效率。结果治疗组总有效率91．38％，对照组A总有效率为68．42％，对照组B总有效率为79．25％，治疗组与对照组A、对照组B比较差异有统计学意义（P〈0．05），3组均未出现血液系统及肝肾功能损害和胃肠道不良反应。结论电针配合口服盐酸氨基葡萄糖胶囊疗效优于单纯电针治疗和单纯口服盐酸氨基葡萄糖胶囊治疗。

Clinical Observation of Electro-acupuncture Combined with Oral Glucosamine Hydrochloride Capsules for the Treatment of Knee Osteoarthritis

Objective To observe the therapeutic effect of electro-acupuncture combined with oral glucosamine hydrochloride capsules in the treatment of knee osteoarthritis, and compare it with the curative effect of the two methods separately. Methods A total of 168 patients with knee osteoarthritis treated from March 2006 to December 2012 were randomly divided into 3 groups. Electro-acupuncture combined with oral glucosamine hydrochloride capsules were given to the 58 patients in the treatment group, single acupuncture treatment was given to the 57 patients in control group A, and simple oral glucosamine hydrochloride capsules were given to the 53 patients in control group B. The treatment lasted for 6 weeks. Assessment of knee osteoarthritis by Lequesne international standard index number and the total efficiency was carried out before treatment and 3 weeks, 6 weeks and 6 months after treatment, respectively. Results The total effective rate of the treatment group was 91.38%, of control group A was 68.42%, and of control group B was 79.25%. There was a significant difference between le treatment group and control group A, and between the treatment group and control group B （P 〈 0.05）. No blood, liver or kidney damage or gastrointestinal adverse reaction occurred among patients in all the three groups. Conclusion The efficacy of electro-acupuncture plus oral glucosamine hydrochloride capsules is better than simple acupuncture and simple oral glucosamine hydrochloride capsules treatment.