雌激素受体和孕激素受体表达与乳腺癌临床病理相关性分析

目的探讨乳腺癌雌激素受体（ER）、孕激素受体（PR）表达及其与乳腺癌各临床病理因素之间的关系。方法收集2011年9月-2012年9月乳腺癌患者105例，用免疫组织化学法检测ER、PR及表皮生长因子受体2（C-erbB-2）并分析其相互关系及与临床各因素之间的关系。结果ER、PR及C-erbB-2的阳性率分别为58．1％、49．5％、59．0％。ER表达与PR表达呈正相关（P〈0．05），ER、PR表达一致率与C-erbB-2表达呈负相关（P〈0．05）。ER表达与淋巴结转移、组织学分级有相关性（P〈0．05），与年龄、月经初潮年龄、肿瘤大小、部位、临床分期、病理类型及癌旁组织病理学形态无关。PR表达及ER不同阳性强度表达与临床病理各因素差异均无统计学意义（P〉0．05）。C．erbB．2在有淋巴结转移组中阳性表达率高于淋巴结未转移组（P〈0．05）。结论ER、PR在乳腺癌发生、发展中发挥着重要作用，联合检测ER、PR对评估乳腺癌患者内分泌治疗效果及预后有重要意义。

Correlation between Expression of Estrogen Receptor and Progesterone Receptor and Clinicopathologic Factors in Patients with Primary Breast Cancer

Objective To explore the correlation of clinicopathologic factors with the expression of estrogen receptor （ER） and progesterone receptor （PR） in patients with primary breast cancer. Methods The data of 105 patients with primary breast cancer were collected from September 2011 to September 2012. The expression of ER, PR and C-erbB-2 in breast cancer tissues was detected by immunohistochemistry. The correlation between the expression of ER, PR and C-erbB-2 and the clinicopathologic factors was evaluated. Results The positive rates of expression of ER, PR and C-erbB-2 in breast cancer tissues reached 58.1%, 49.5% and 59.0%, respectively. The expression of ER had a positive correlation with the expression of PR. The concordance expression of ER and PR had a negative correlation with the expression of C-erbB-2. The positive rate of expression of ER had a correlation with the lymph node metastasis and histological grading, while it was not correlated with patients＇ age, the age of menarche, tumor size, tumor position, clinical stages, pathological type, or pathologic morphology of tissue adjacent to cancer （P 〉 0.05）. The positive rate of expression of PR and the different positive strength rate of expression of Eg were not correlated with clinical and pathological factors （P 〉 0.05）. The positive rate of expression of C-erbB-2 in the group with lymph node metastasis was higher than that in non-lymph node metastasis group （P 〈 0.05）. Conclusions The expression of ER and PR plays an important role in the occurrence and development of the breast cancer. Joint detection of ER and PR is very important for the evaluation of endocrine therapy effect and prognosis.