脑梗死患者急性期凝血功能相关指标的检测及意义

目的：观察脑梗死患者急性期凝血功能相关指标的变化情况及探讨其临床意义。方法：选取96例脑梗死急性期患者，测定其急性期凝血酶原时间（PT）、活化部分凝血酶原时间（APTT）、凝血酶时间（TT）、纤维蛋白原（FIB）、D一二聚体（DD）及平均血小板体积（MPV）变化，将急性期水平与67例非心脑血管疾病病人对照进行比较，并从脑梗死患者中选取83例，测定其恢复期相关指标水平，与急性期进行比较。结果：脑梗死患者急性期PT和APTT低于对照组，FIB、DD和MPV高于对照组，差异具有统计学意义（P〈0．05），而TT差异不具有统计学意义；同一患者恢复期的PT和APTT水平高于急性期，FIB和DD水平低于急性期，差异具有统计学意义（P〈0．05），而TT和MPV的变化不具有统计学差异。结论：脑梗死患者急性期APTT、PT、FIB、D-二聚体和MPV异常，检测脑梗死患者急性期凝血功能各项指标和D一二聚体含量的变化可为脑梗死的辅助诊断、疗效观察和预后监测提供重要的依据

Levels and clinical significance of the indexes related to coagulation function in patients with acute cerebral infarction

Objective,To observe the changes of indexes related to coagulation function in patients with acute cerebral infarction and to investigate their clinical significance. Methods. Prothrombin time （PT）, activated partial thromboplastion time （APTT）, thrombin time （TT）, fibrinogen （FIB）, D-dimer （DD） and mean platelet volume （MPV） in 96 patients with acute cerebral infarction and 67 controls with- out any cardio-cerebrovascular disease were measured. Levels of these indexes were compared between pa- tient group and control group, and between recovery stage and acute stage. Results.PT and APTT in the patients with acute cerebral infarction were significantly shorter than the controls, and levels of FIB, I）D and MPV were significantly higher than the controls（P0.05）, while the differences of TT were not sig nificant. During recovery stage, PT and APTT of one patient were higher than levels during the acute