BAG-1基因与乳腺癌TAM治疗敏感性的相关性研究

目的研究BAG-1基因与乳腺癌他莫昔芬(TAM)治疗敏感性的相关性。方法以58例乳腺癌患者为观察组,50例乳腺良性肿瘤患者为对照组。予以观察组患者TAM治疗,检测并统计2组患者肿瘤组织BAG-1基因的阳性率;并根据检测结果将观察组患者分为BAG-1阳性组与阴性组,对比分析观察组BAG-1阳性者与阴性者的临床预后及血清肿瘤标志物水平,包括癌胚抗原(CEA)、糖类抗原153(CA153)。结果观察组BAG-1基因阳性率为74.14%,对照组为12%,2组比较,P<0.05。观察组BAG-1阳性组患者临床缓解率为46.51%,阴性组为66.67%,2组比较,P<0.05;BAG-1阳性组患者临床控制率为67.44%,阴性组为86.67%,2组比较,P<0.05。观察组BAG-1阳性组患者平均OS为(1.55±0.86)a,PFS为(1.02±0.31)a,阴性组依次为(2.76±0.95)a、(2.06±0.82)a,2组比较,差异均有统计学意义(P<0.05)。治疗后,观察组BAG-1阴性组患者血清CEA、CA153指标值均低于对照组(P<0.05)。结论 BAG-1基因与乳腺癌TAM治疗敏感性密切相关,BAG-1阳性者行TAM治疗的临床效果及预后均较阴性者差。

Correlation of BAG-1 gene with sensitivity of TAM to breast cancer

Objective To study the correlation between BAG-1 gene and the sensitivity of tamoxifen (TAM)in breast cancer. Methods 58 cases of breast cancer patients as the observation group,50 cases of benign breast cancer pa-tients as the control group. The positive rate of BAG-1 gene in two groups of patients was detected and statistically analyzed by TAM. The patients in the observation group were divided into BAG-1 positive group and negative group according to the test results,and the positive rate of BAG-(CEA),carbohydrate antigens 153 (CA153)and carcinoembryonic antigen (CEA). Results The positive rate of BAG-1 gene was 74. 14% in the observation group and 12% in the control group,P<0. 05. The clinical response rate of BAG-1 positive group was 46. 5 1% and negative group was 66. 67%,P<0. 05;The clinical control rate of BAG-1 positive group was 67. 44%,negative group was 86. 67%. Compared 2 groups ,it was P<0. 05. The mean OS was (1. 55 ±0. 86)years,PFS was (1. 02 ±0. 31)years in the BAG-1 positive group and (2. 76 ±0. 95)years in the negative group and (2. 06 ±0. 82)years in the negative group,(P<0. 05). After treatment,the serum CEA and CA153 values in the negative group of BAG-1 were lower than those in the control group (P<0. 05 ). Conclusion BAG-1 gene and breast cancer TAM treatment sensitivity is closely related to BAG-1 positive TAM treatment of clinical efficacy and prognosis were worse than negative.