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| VEGF和C-myc表达在胆囊癌形成、发展和转移中的作用 | |
| 引用本文： | 刘智敏,蒋莉莉,阳斌,廖殿英. VEGF和C-myc表达在胆囊癌形成、发展和转移中的作用[J]. 生物医学工程学杂志, 2003, 20(1): 68-70 |
| 作者姓名： | 刘智敏 蒋莉莉 阳斌 廖殿英 |
| 作者单位： | 1. 四川大学,华西医院,外科实验室,成都,610041 2. 四川大学,华西医院,病理科,成都,610041 |
| 摘 要： | 应用免疫组化ABC法对30例胆囊癌的癌组织VEGF和C－myc的表达进行检测，以探讨VEGF和C－myc在胆囊癌中的表达和二者之间的相关性以及胆囊癌形成，发展和转移中的作用。结果发现VEGF和C－myc二者在胆囊癌组织和正常胆囊组织中的阳性表达率均有显著性差异（P＜0．05），VEGF与C－myc的表达呈非常显著的相关性（P＜0．01），二者的表达与胆囊癌的转移行为有关，而与肿瘤的分化程度无关，VEGF与C－myc基因协同作用在胆囊癌形成，发展和转移中起着重要作用。 |
| 关 键 词： | VEGF C－myc 胆囊癌 血管内皮生长因子 肿瘤形成 肿瘤转移 |
The Roles of VEGF and C-myc in Occurrence, Development and Metastasis of Gallbladder Carcinoma |
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| Liu Zhimin Jiang Lili Yang Bin Liao Dianying. The Roles of VEGF and C-myc in Occurrence, Development and Metastasis of Gallbladder Carcinoma[J]. Journal of biomedical engineering, 2003, 20(1): 68-70 | |
| Authors: | Liu Zhimin Jiang Lili Yang Bin Liao Dianying |
| Affiliation: | Laboratory of Surgical Department, West China Hospital, Sichuan University, Chengdu 610041. |
| Abstract: | To investigate the relationship of the expression of vascular endothelial growth factor (VEGF) and C-myc with the occurrence, development and metastasis of gallbladder carcinoma, the expression levels of VEGF and C-myc in gallbladder carcinoma tissue (n=30) and in normal gallbladder tissue(n=20) were examined by immunochemistry. Results show that the positive rates of VEGF and C-myc in gallbladder carcinoma tissue were 80% and 63.3% respectively, and 45% and 25% respectively in normal gallbladder tissue. The positive rates of VEGF and C-myc were significantly higher in gallbladder carcinoma than in normal gallbladder tissue. The expression of VEGF and C-myc in gallbladder carcinoma related to the metastasis of gallbladder carcinoma. VEGF and C-myc play important roles in the occurrence, development and metastasis of gallbladder carcinoma. |
| Keywords: | Gallbladder carcinoma Vascular endothelial growth factor C-myc |
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