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| Effect of tetramethylpyrazine on P-selectin and hepatic／rena ischemia and reperfusion injury in rats | |
| 引用本文： | Chen JL,Zhou T,Chen WX,Zhu JS,Chen NW,Zhang MJ,Wu YL. Effect of tetramethylpyrazine on P-selectin and hepatic／rena ischemia and reperfusion injury in rats[J]. World journal of gastroenterology : WJG, 2003, 9(7): 1563-1566. DOI: 10.3748/wjg.v9.i7.1563 |
| 作者姓名： | Chen JL Zhou T Chen WX Zhu JS Chen NW Zhang MJ Wu YL |
| 作者单位： | Jin-Lian Chen,Wei-Xiong Chen,Jin-Shui Zhu,Ni-Wei Chen(Department of Gastroenterology, Shanghai Sixth People's Hospital,Shanghai Jiao-Tong University, Shanghai 200233, China);Tong Zhou(Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China);Ming-Jun Zhang(Animal Laboratory, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China);Yun-Lin Wu(Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China) |
| 基金项目： | 国家自然科学基金,卫生部科研项目 |
| 摘 要： | |
| 关 键 词： | 川芎嗪 P-选择素 肝 肾 缺血再灌注损伤 中性粒细胞 |
| 收稿时间： | 2002-12-30 |
Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats |
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| Chen Jin-Lian,Zhou Tong,Chen Wei-Xiong,Zhu Jin-Shui,Chen Ni-Wei,Zhang Ming-Jun,Wu Yun-Lin. Effect of tetramethylpyrazine on P-selectin and hepatic/renal ischemia and reperfusion injury in rats[J]. World journal of gastroenterology : WJG, 2003, 9(7): 1563-1566. DOI: 10.3748/wjg.v9.i7.1563 | |
| Authors: | Chen Jin-Lian Zhou Tong Chen Wei-Xiong Zhu Jin-Shui Chen Ni-Wei Zhang Ming-Jun Wu Yun-Lin |
| Affiliation: | 1. Department of Gastroenterology, Shanghai Sixth People's Hospital,Shanghai Jiao-Tong University, Shanghai 200233, China 2. Department of Nephrology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China 3. Animal Laboratory, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China 4. Department of Gastroenterology, Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025, China |
| Abstract: | AIM: To investigate the effect of tetramethylpyrazine on hepatic/renal ischemia and reperfusion injury in rats. METHODS: Hepatic/renal function, histopathological changes, and hepatic/renal P-selectin expression were studied with biochemical measurement and immunohistochemistry in hepatic/renal ischemia and reperfusion injury in rat models. RESULTS: Hepatic/renal insufficiency and histopathological damage were much less in the tetramethylpyrazine-treated group than those in the saline-treated groups. Hepatic/renal P-selectin expression was down regulated in the tetramethylpyrazine-treated group. CONCLUSION: P-selectin might mediate neutrophil infiltration and contribute to hepatic/renal ischemia and reperfusion injury. Tetramethylpyrazine might prevent hepatic/renal damage induced by ischemia and reperfusion injury through inhibition of P-selectin. |
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