重症心肌炎合并多脏器功能不全临床分析

目的：探讨重症病毒性心肌炎合并多脏器功能不全(MODS)的治疗及预防。方法：64例重症心肌炎，有8例合并3个以上脏器功能损害，给予改善心肌缺氧和微循环，清除自由基，抗感染从而阻止肿瘤坏死因子(TNF)、血浆内皮素(ET)的形成。结果：本组治愈6例，死亡2例，在治疗初始就注意保护各脏器功能，防止MODS发生，疗效满意。结论：重症心肌炎并发MODS主要因素是脏器灌注不足，血细胞超氧歧化酶(SOD)降低，血浆脂质过氧化物LOP增高，TNF、EI升高，引起微循环障碍，组织脏器缺氧加重。造成MODS。

Clinical Analysis of Severe Myocarditis with Mutiple Organ Dysfunction

Objective To inquire into the treatment and prevention of severe myocarditis with multiple organ dysfunction (MODS).Methods Of 64 patients with severe myocarditis,there were 8 with the injury of more than 3 system organs.Myocardial anoxia and microcirculation were improved,free radical was cleaned and anti-infection carried out in order to prevent the formation tumor necrosis factor(TNF) and endothelin(ET).Results Of these patients,6 were cured and 2 died;at the beginning of the treatment,the authors attached great importance to the protection of all the organs to prevent the occurrence of MODS.And the effect was favourable. Conclusion Severe myocarditis with MODS is mainly due to organ hypoperfusion,decreased superoide dismutase(SOD),and increased lipid peroxide(LOP) and TNF and ET,which causes microcirculation dysfunction and more severe tissue organ anoxia.Thus MODS occurs.