Effects of trophic 2,2′, 4,4′-tetrabromodiphenyl ether (BDE-47) exposure in Oreochromis niloticus: A multiple biomarkers analysis |
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| Institution: | 1. Departamento de Biologia Celular, Universidade Federal do Paraná, Caixa Postal 19031, CEP 81531-970, Curitiba, PR, Brazil;2. Departamento de Toxicologia Molecular e Ambiente, Centro de Biotecnologia, Universidade Eduardo Mondlane (CB-UEM), Maputo, Mozambique;3. Programa de Pós-graduação em Agroecossistemas, Universidade Tecnológica Federal do Paraná, Campus Dois Vizinhos, CEP 82660-000, Dois Vizinhos, PR, Brazil;4. Programa de Pós-graduação em Ecotoxicologia, Universidade Tecnológica Federal do Paraná, Campus Curitiba, CEP 81280-340, Curitiba, PR, Brazil;5. Estação de Piscicultura Panamá, Est. Geral Bom Retiro, Paulo Lopes, SC, CEP 88490-000, Brazil;1. Laboratory of Environmental Chemistry and Toxicology, Department of Environmental Health Science, IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Milano, Italy;2. Interdisciplinary Center for Nanotoxicity, Department of Chemistry, Physics, and Atmospheric Sciences, Jackson State University, Jackson, MS, USA;3. Department of Informatics, Postdoctoral Institute for Computational Studies, Enfield, NH, USA;4. The Ronin Institute of Independent Scholarship, Montclair, NJ, USA;1. Department of Environmental Science and Policy, University of Milan, via Celoria 26, 20133, Milan, Italy;2. Department of Animal Ecology I and BayCEER, University of Bayreuth, Universitaetsstraße 30, 95447, Bayreuth, Germany;1. Department of Pharmacological & Pharmaceutical Sciences, University of Houston, Houston, TX, United States;2. Translational Medicine Department, QPS, LLC, Newark, DE, United States;1. Center for Disease Control and Prevention, Chinese PLA, No. 20 Dongdajie Street, Fengtai Area, Beijing, 100071, China;2. School of Public Health, China Medical University, No. 77 Puhe Road, Shenyang North New Area, Shenyang, 110122, China;3. Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, No.23 Back District, Dongcheng Area, Beijing, 100010, China;1. State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;2. Shanghai Collaborative Innovation Centre for WEEE Recycling, WEEE Research Centre of Shanghai Polytechnic University, Shanghai, 201209, China;1. State Key Laboratory of Urban and Regional Ecology, Research Centre for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, PR China;2. CAS Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization & Ecological Restoration Biodiversity Conservation Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, PR China;3. University of Chinese Academy of Sciences, Beijing 100039, PR China |
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| Abstract: | Polybrominated diphenyl esters are emerging environmental contaminants with few toxicological data, being a concern for the scientific community. This study evaluated the effects of BDE-47 on the health of Oreochromis niloticus fish. The animals were exposed to three doses of BDE-47 (0, 0.253, 2.53, 25.3 ng g−1) every 10 days, for 80 days. The BDE-47 affected the hepatosomatic and gonadosomatic index in female and the condition factor by intermediate dose in both sexes. The levels of estradiol decreased and the T4 are increased, but the vitellogenin production was not modulated in male individuals. Changes in AChE, GST, LPO and histopathology were observed while the integrated biomarker response index suggests that the lowest dose of BDE-47 compromised the activity of antioxidant enzymes. The oral exposure to BDE-47 in environmental concentrations is toxic to O. niloticus and the use of multiple biomarkers is an attribution in ecotoxicology studies and biomonitoring programs. |
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| Keywords: | BDE-47 Trophic exposure Water quality Biomarkers Toxicity |
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