Visual dysfunction is associated with cognitive impairment in Parkinson's disease |
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| Affiliation: | 1. Neurodegenerative Diseases Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Bizkaia, Spain;2. Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain;3. Computational Neuroimaging Group, Biocruces Bizkaia Health Research Institute, Barakaldo, Spain;4. Department of Cell Biology, University of the Basque Country (UPV/EHU), Leioa, Spain;5. Neurology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain;6. Ophthalmology Department, Cruces University Hospital, Barakaldo, Bizkaia, Spain;7. Department of Neuroscience, University of the Basque Country (UPV/EHU), Leioa, Spain;8. Ikerbasque: the Basque Foundation for Science, Bilbao, Spain;1. Department of Neurology, Wake Forest School of Medicine, 1 Medical Center, Boulevard, Winston-Salem, NC, 27157, USA;2. Icahn School of Medicine at Mount Sinai, 1000 10th Ave., Suite 10c, New York, NY, 10019, USA;3. Cleveland Clinic Lou Ruvo Center for Brain Health, 888 W Bonneville Ave, Las Vegas, NV, 89117, USA;4. Cleveland Clinic, 9500 Euclid Ave/S2, Cleveland, OH, 44195, USA;5. Pennsylvania State University – Milton S. Hershey Medical Center, 30 Hope Drive, Suite 2800 P.O. Box 859, Mail Code EC037, Hershey, PA, 17033, USA;6. Mount Sinai Medical Center, 1000 10th Ave, Suite 10C, Brooklyn, NY, 11217, USA;7. Henry Ford Medical Group, 6777 West Maple Road, West Bloomfield, MI, 48322, USA;8. Baylor College of Medicine, 7200 Cambridge St, 9th Floor, Houston, TX, 77030, USA;9. Weill Cornell Medicine, 428 E 72nd Street, STE 400, NY, NY, 10021, USA;10. University of Nebraska Medical Center, 988440 Nebraska Medical Center, Omaha, NE, 68198, USA;11. Rush University Medical Center, 1725 West Harrison St. Suite 755, Chicago, IL, 60612, USA;12. UCDavis, 4860 Y Street, ACC Building, Suite 3700, Sacramento, CA, 95817, USA;13. Penn State Health, Milton S. Hershey Medical Center, Department of Neurosurgery, 30 Hope Drive, EC110, Hershey, PA, 17033, USA;14. Northwestern University Feinberg School of Medicine Department of Neurosurgery, 676 N St. Clair St, Suite 2210, Chicago, IL, USA;1. James J. and Joan A. Gardner Family Center for Parkinson''s Disease and Movement Disorders, Department of Neurology, University of Cincinnati, Cincinnati, OH, USA;2. Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA, United States;3. Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA;4. Department of Laboratory Medicine, Clinical Research Center, Karolinska Institutet, Stockholm, Sweden;5. Department of Clinical Neuroscience, Neuro Svenningsson, Karolinska Institute, 171 76, Stockholm, Sweden;1. Movement Disorders Section, Neuroscience Department, Fleni, Buenos Aires, Argentina;2. National Research Council (CONICET), Buenos Aires, Argentina;3. Faculty of Medicine, Pontifical Catholic University of Argentina, Buenos Aires, Argentina;4. Universidad Abierta Interamericana, Centro de Altos Estudios en Ciencias Humanas y de la Salud (UAI-CAECIHS), Buenos Aires, Argentina;5. Department of Physiology, Faculty of Medicine, University of Buenos Aires, Argentina;1. CognitionMetrics, LLC, Wilmington, DE, USA;2. Biogen, Cambridge, MA, USA |
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| Abstract: | ![]()
IntroductionVisual dysfunction and cognitive impairment are common in Parkinson's disease (PD) but the precise contribution of lower-level visual impairment to visual-input based cognitive performance has not been extensively characterized in PD.MethodsWe included 49 PD patients and 22 healthy controls (HC). Lower-level visual function tests [high and low contrast visual acuity (HCVA and LCVA) and contrast sensitivity (CS)] and a neuropsychological battery (involving visual cognition) were performed. Pairwise correlations between lower-level visual functions and visual cognition were computed and stepwise linear regressions were fitted introducing age, Geriatric Depression Scale, and lower-level visual functions in the model to calculate their predicted effect on visual cognition.ResultsCompared to controls, patients presented a significant impairment in all cognitive domains (visual attention, visual processing speed and visual perception, visuospatial abilities, visuoconstructive abilities, and visual memory), and lower-level visual functions. HCVA and LCVA were significantly associated with visual cognition in PD. HCVA explained up to 49.3% and 34.2% of the variability in visual perception and visuospatial abilities, respectively, whereas LCVA was mainly associated with short- and long-term visual memory and visuospatial abilities.ConclusionLower-level visual dysfunction is highly associated with cognitive performance in PD, when cognitive tests are based on visual input. Our results support that lower-level visual functions should be considered when assessing cognitive status of PD patients and might be useful for predicting cognitive deterioration. |
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| Keywords: | Cognition Parkinson's disease Visual cognition Visual function |
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