Revision knee replacement for prosthetic joint infection: Epidemiology,clinical outcomes and health-economic considerations |
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| Affiliation: | 1. The Stavros Niarchos Foundation Complex Joint Reconstruction Center, Hospital for Special Surgery, New York, NY;2. Department of Orthopedics and Traumatology, Clinica Ars Medica, Gravesano, Ticino, Switzerland;3. Department of Orthopedics, Balgrist University Hospital, University of Zurich, Zurich, Switzerland;4. Department of Orthopaedics, IRCCS Istituto Ortopedico Galeazzi, Milano, Italy;5. Hadassah Medical Center, Jerusalem, Israel;1. University Hospital Llandough & Spire Hospital, Cardiff, United Kingdom;2. Schoen Clinic Orthopaedic and Spinal Hospital, 66 Wigmore Street, London W1U 2SB, United Kingdom;3. Schoen Clinic Orthopaedic and Spinal Hospital, London 66, Wigmore Street, London W1U 2SB |
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| Abstract: | Prosthetic joint infection (PJI) is a devastating complication of knee replacement surgery. Recent evidence has shown that the burden of disease is increasing as more and more knee replacement procedures are performed. The current incidence of revision total knee replacement (TKR) for PJI is estimated at 7.5 cases per 1000 primary joint replacement procedures at 10 years. Revision TKR for PJI is complex surgery, and is associated to a high rate of post-operative complications. The 5-year patient mortality is comparable to some common cancer diagnoses, and more than 15% of patients require re-revision by 10 years. Patient-reported outcome measures (PROMs) including joint function may be worse following revision TKR for PJI than for aseptic indications. The complexity and extended length of the treatment pathway for PJI places a significant burden on the healthcare system, highlighting it as an area for future research to identify the most clinically and cost-effective interventions. |
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| Keywords: | Knee Arthroplasty Peri- prosthetic joint infection Epidemiology Morbidity Mortality Patient reported outcome (PROM) Health-economics |
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