| 乳腺癌患者血清中巨噬细胞移动抑制因子的临床意义 |
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| 引用本文： | 徐向东,汪波,姚陈,林颖,王深明. 乳腺癌患者血清中巨噬细胞移动抑制因子的临床意义[J]. 中华普通外科学文献(电子版), 2011, 5(2): 140-143. DOI: 10.3877/cma.j.issn.1674-0793.2011.02.013 |
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| 作者姓名： | 徐向东 汪波 姚陈 林颖 王深明 |
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| 作者单位： | 1. 中山大学附属第一医院乳腺病治疗中心,广州,510080
2. 中山大学附属第一医院检验科,广州,510080 |
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| 摘 要： | 目的探讨乳腺癌患者血清巨噬细胞移动抑制因子（MIF）水平与其临床特征的关系.方法收集2006年10月至2007年3月乳腺癌患者54例和体检正常的女性健康对照46例血清,用酶联免疫吸附法检测血清MIF、白细胞介素8（IL-8）及血管内皮生长因子（VEGF）的浓度,分析其与临床特征的关系.结果乳腺癌组血清MIF、IL-8及VEGF浓度均明显高于健康对照组（P＜0.05）,MIF与肿瘤的分期和淋巴结转移相关（P＜0.05）,乳腺癌组患者血清MIF与IL-8相关（r=0.612,P＜0.01）.结论 MIF可能参与了乳腺癌的疾病进展过程,可作为反应肿瘤侵袭的一个有用的生物标记物.
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| 关 键 词： | 乳腺癌 巨噬细胞移动抑制因子 IL-8 VEGF |
Serum levels of macrophage migration inhibitory factor in patients with breast cancer and its clinical significance |
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| XU Xiang-dong,WANG Bo,YAO Chen,LIN Ying,WANG Shen-ming. Serum levels of macrophage migration inhibitory factor in patients with breast cancer and its clinical significance[J]. Chinese Journal of General Surgery(Electronic Version), 2011, 5(2): 140-143. DOI: 10.3877/cma.j.issn.1674-0793.2011.02.013 |
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| Authors: | XU Xiang-dong WANG Bo YAO Chen LIN Ying WANG Shen-ming |
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| Affiliation: | XU Xiang-dong,WANG Bo,YAO Chen,LIN Ying,WANG Shen-ming.Center of Breast Disease,the First Affiliated Hospital,SUN Yat-Sen University,Guangzhou 510080,China |
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| Abstract: | Objective To study the relationship between serum macrophage migration inhibitory factor(MIF) levels and clinical features in the patients with breast cancer.Methods Enzyme-linked immunosorbent assay was used to detect the concentration of MIF,IL-8 and VEGF in sera of 54 patients with breast cancer and 46 healthy controls from October 2006 to March 2007.The relationship between serum MIF,IL-8 and VEGF levels and clinical features was analyzed.Results The levels of MIF,IL-8 and VEGF in the sera of patients w... |
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| Keywords: | IL-8 VEGF |
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