| 预处理对在体大鼠心肌细胞的保护作用 |
| |
| 引用本文： | 张梅,黄体钢,杨万松,陈元禄,周丽娟.预处理对在体大鼠心肌细胞的保护作用[J].实用心脑肺血管病杂志,2002,10(2):67-70. |
| |
| 作者姓名： | 张梅 黄体钢 杨万松 陈元禄 周丽娟 |
| |
| 作者单位： | 300211,天津医科大学第二医院 |
| |
| 摘 要： | 目的：探讨缺血预处理对心肌细胞的保护作用。方法：在体大鼠心肌细胞缺血／复灌模型中，观察缺血预处理对心肌细胞再次长时间缺氧／复氧或缺血／复灌损伤的保护作用（LDH释放，MDA，SOD的含量和心肌梗死范围及心律失常等）。结果；在体大鼠心肌缺血预处理组梗死范围和血清LDH较缺血复灌组减少（P＜0．01），预处理组MDA较缺血复灌组也显著降低（P＜0．01）。而且无论是再次的缺血还是复灌期室性心律失常的发生率预处理组明显低于非预处理组（P＜0．01）。结论：缺血预处理可以减少再次长时间的缺血／复灌对心肌的损伤。
|
| 关 键 词： | 大鼠 保护作用 缺血预处理 心肌缺血 再灌注 |
Effects of ischemic preconditioning on cardiomyocytes in rat hearts in vivo |
| |
| Zhang Mei,Huang Tigang,Yang Wansong,et al..Effects of ischemic preconditioning on cardiomyocytes in rat hearts in vivo[J].Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease,2002,10(2):67-70. |
| |
| Authors: | Zhang Mei Huang Tigang Yang Wansong |
| |
| Institution: | Zhang Mei,Huang Tigang,Yang Wansong,et al. The Second Hospital,Tianjin Medical University 300211 |
| |
| Abstract: | ve To investigate the effects of ischemic preconditioning on cardiomyocytes. Methods In situ rat hearts, the present study observes the effects of preconditioning (PC) on ischemia/reperfusion(I/R) injury on cardiomyocytes. The infarct size, LDH release and the content of MDA were measured. Results In situ rat hearts, ischemic PC decreased the injuries to cardiac myocytes. The plasma LDH levels, tissue MDA contents, the infarct sizes and arrhythmia during occlusion or reperfusion were greatly decreased in preconditioned myocardium after a long time (I/R) than those in the unpreconditioning( P < 0.01) . Conclusion PC can obviously protect ischemia/reperfusion injured in situ rat heart. |
| |
| Keywords: | Ischemic Preconditioning Ischemia/Reperfusion Cardiomyocytes |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
|
