蛇床子提取液的局部麻醉作用

蛇床子提取液对蟾蜍离体坐骨神经有阻滞麻醉作用;对豚鼠有浸润麻醉作用,并可被盐酸肾上腺素所增强;对家兔有椎管麻醉作用,但对兔角膜没有表面麻醉作用;可明显增强阈下催眠剂量的戊巴比妥钠对小鼠的催眠作用。

Local Anesthetic Effect of Aqueous Extract from the Seeds of Cnidium monnieri (L.) Cusson

The aqueous extract prepared from the seeds of Cnidium monnieri possesses a blocking anesthetic action on isolated sciatic nerves in toads. The experiments on guinea pig wheal show that the preparation induces an infiltration anesthetic effect, which may be potentiated by epinephrine hydrochloride. In rabbits, the extract injected into the subarachnoid space of the lumber area almost immediately initiates the on set of anesthetic action on the cornea. Furthermore, the aqueous extract can potentiate the hypnotic effect of pentobarbital sodium in mice.