Enhancement of diethylnitrosamine hepatocarcinogenesis in rats by exposure to polychlorinated biphenyls or phenobarbital. |
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| Authors: | M Nishizumi |
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| Affiliation: | Department of Public Health, Faculty of Medicine, Kyushu University, Maedashi 3-1-1, Higashiku, Fukuoka 812 (Japan) |
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| Abstract: | ![]()
Diethylnitrosamine (DENA) hepatocarcinogenesis was enhanced by sequential exposure with polychlorinated biphenyls (PCBs) and with phenobarbital. This was shown by the earlier appearance of tumors and a significant increase in the number of tumors. However, there was no evidence suggesting an acceleration of tumor growth. |
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