广东高州市23价肺炎球菌多糖疫苗接种副反应监测

目的监测广东高州市23价肺炎多糖疫苗副反应发生情况,便于指导今后的处理工作。方法对2岁以上体弱儿童和50岁以上老人在知情、同意、自愿的原则下,统一接种成都生物制品研究所生产的23价多糖肺炎疫苗。接种后30d内以填卡方式进行副反应的跟踪随访监测,主要监测局部反应和全身反应,30d后回收监测卡进行分析。结果共观察接种1166人,回收有效监测卡1016张,年龄最小2岁,最大72岁,19张卡有副反应报告,轻微副反应发生率为1.87%,其中局部副反应发生率为1.18%,全身副反应发生率为1.97%,未见严重和罕见副反应。结论成都生物制品研究所生产的23价肺炎球菌多糖疫苗安全性高,接种后副反应发生率低。

Monitoring of side effects 23-valent pneumococcal polysaccharide vaccine after vaccination

Objective To monitor the side effects of the 23-valent pneumococcal polysaccharide vaccine.Methods The weak children aged two years and above and the elderly over age of 50 years were immunized with the 23-valent pneumococcal polysaccharide vaccine.Then the local and general side effects of the vaccine were monitored within 30 days after vaccination under principles of informed consent and voluntary acceptance.Results A total of 1 166 vaccinated persons aged from 2 years old to 72 years old were monitored and 1 016 valid monitoring cards were recovered.Side effects occurred to 19 persons with an mild side effects incidence of 1.87% including the local side reaction rate of 1.18% and general side reaction rate of 1.97%.No severe side effects were observed.Conclusions The 23-valent pneumococcal polysaccharide vaccines produced by Chengdu Institute of Biological Products is safe with low incidence of side effects after inoculation.