我院ICU万古霉素使用情况临床分析

目的为了了解我院ICU万古霉素临床使用情况，以指导今后规范和合理使用万古霉素。方法回顾性分析我院ICU万古霉素的消耗、利用情况和耐甲氧西林金黄色葡萄球菌（MRSA）的检出情况以及对2008年1月至2009年6月使用万古霉素患者进行临床用药分析。结果2007年万古霉素消耗量最大为728．0g，MRSA检出率最高，ICU为52株（70．oo％），全院为115株（49．00％）。MRSA平均检小率为62．8％。74例使用万占霉素患者中最常用的初始方案1g／12h。结论我院ICU万古霉素使用基本合理，今后需加强血药浓度监测，利用药效学和药动学理论，实施个体化给药办案。

Clinical analysis of vancomycin usage in intensive care unit

Objectives To investigate vancomycin usage in ICU and to rationalize the use of vancomycin.Methods Vancomycin consumption, usage and methicillin-resistant staphylococcus aureus case detection rate of vancomycin in our hospital were retrospectively analyzed. From January 2008 to June 2009, the clinical usage of vancomycin was analyzed. Results The consummation of vancomycin in 2007 was more than other years and so was the incidence rate of MRSA. The average incidence rate of MRSA was 62. 8% in ICU. The regimen of 1 g q12h was used most frequently in the 74 study cases. Conclusions The usage of vancomycin in ICU of our hospital was basi-cally reasonable. Blood concentration monitoring should be strengthened in the future. Personalized administration plan should be implemented by pharmacodynamic and pharmacokinetic theory.