鼻腔鼻窦恶性黑色素瘤24例报告

目的：探讨鼻腔鼻窦恶性黑色素瘤的病理、临床特点及治疗方法。方法：鼻腔鼻窦恶性黑色素瘤24例中，鼻侧切开鼻腔鼻窦肿瘤切除术18例，颈外动脉结扎上颌骨大部分切除术2例，上颌窦根治术径路鼻腔鼻窦肿瘤切除术2例，颅面联合径路前颅底鼻腔鼻窦肿瘤切除术2例，同期行颈淋巴清扫术4例；单纯手术14例，手术加术后放疗8例，手术加放疗和化疗2例，其中1例加免疫治疗（IL-2和IFN）。结果：24例患者中随访22例，失访2例，3年生存率为54．5％（12／22），5年生存率为31．8％（7／22）。结论：鼻腔鼻窦恶性黑色素瘤恶性程度高，易复发，早期诊断、根治性手术切除能提高本病生存率。

Sinonasal malignant melanoma: 24 cases report

Objective:To review the pathological and clinical features and treatment of sinonasal malignant melanoma.Method:Twenty-four patients with sinonasal malignant melanoma were surgically treated,18 cases were treated with lateral rhinotomy,two cases with partial maxillectomy and ligation of external carotid artery,two cases with Caldwell-Luc technique,two cases with craniofacial approach,four cases with neck dissection.Among them, 14 patients were only treated by operation, eight cases by operation and radiotherapy, two cases combined by operation, radiotherapy and chemotherapy.Result:Twenty-two patients were followed up, the survival rates of 3 and 5 years were 54.5%(12/22) and 31.8%(7/22) ,respectively.Conclusion:Sinonasal malignant melanoma has an aggressive behavior and easy recurrence. Early diagnosis and radical operation can improve the survival rate.