|
|||||
|
|
| 斑蝥素非离子表面活性剂囊泡的制备及其体外特性表征 | |
| 引用本文： | 李慧,方清影,张红,臧琛,张保献,聂其霞,王国华. 斑蝥素非离子表面活性剂囊泡的制备及其体外特性表征[J]. 中国中药杂志, 2010, 35(19): 2546-2550 |
| 作者姓名： | 李慧 方清影 张红 臧琛 张保献 聂其霞 王国华 |
| 作者单位： | 1. 中国中医科学院,北京,100700 2. 中国中医科学院,北京,100700;安徽中医学院,安徽,合肥,330004 3. 中国中医科学院,北京,100700;江西中医学院,江西,南昌,330003 |
| 基金项目： | 中国中医科学院自主选题项目(ZZ2006118,Z02094) |
| 摘 要： | 目的:以非离子表面活性剂为载体材料进行斑蝥素囊泡的制备考察,并评价其特性表征。方法:建立了注入法制备斑蝥素非离子表面活性剂泡囊的制备工艺;采用离心法和HPLC法测定斑蝥素囊泡的包封率;考察不同处方因素对囊泡体外表征的影响,在此基础上正交设计优化处方;对最佳处方囊泡的形态学、粒径、Zeta电位等性质进行了考察。结果:注入法获得的CTD-NS的包封率为(27.5±2.0)%,粒径(209.8±0.5)nm,Zeta电位(41.5±0.65)mV。结论:以非离子表面活性剂A和B联用为载体材料,注入法制备斑蝥素非离子表面活性剂囊泡,制备方法简单,性质稳定。 |
| 关 键 词： | 斑蝥素 注入法 非离子表面活性剂 囊泡 |
| 收稿时间： | 2010-05-10 |
Preparation and characterization of non-ionic surfactant vesicle of cantharidin |
|
| LI Hui,FANG Qingying,ZHANG Hong,ZANG Chen,ZHANG Baoxian,NIE Qixia and WANG Guohua. Preparation and characterization of non-ionic surfactant vesicle of cantharidin[J]. China Journal of Chinese Materia Medica, 2010, 35(19): 2546-2550 | |
| Authors: | LI Hui FANG Qingying ZHANG Hong ZANG Chen ZHANG Baoxian NIE Qixia WANG Guohua |
| Affiliation: | Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China;College of Pharmacy, Anhui College of Tranditional Chinese Medicine, Hefei 230031, China;Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China;College of Pharmacy, Jiangxi College of Traditional Chinese Medicine, Nanchang 330006, China;Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China;Institute of Chinese Materia Medica, Chinese Acadamy of Chinese Medical Science, Beijing 100700, China |
| Abstract: | Objective : To study the preparation of cantharidin entrapped non-ionic surfactant vesicle(noisome)and evaluate its quality. Method : The niosome loaded with cantharidin was prepared using injection method by non-ionic surfactants as the carrier. An centrifugation separation method and HPLC analysis method of the cantharidin were established to detect the entrapment efficiency. The optimum preparation technology was established by a orthogonal experiment. The morphology, and particle size were studied to evaluate the preparation. Result: The average size of niosomes were(209.8±0.5)nm.The entrapment efficiency of the CTD-NS was(27.5%±2.0%)and Zeta potential was (41.5±0.65)mV. Conclusion :The preparation of cantharidin noisome by TweenA and SpanB is practicable and successful. These experiments can be the basement of developing targeting drug delivery system. |
| Keywords: | cantharidin injection method non-ionic surfactant niosome |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |