HER2阳性早期乳腺癌全身治疗变革及未来展望

近二十年来,随着HER2靶向药物的出现和发展,HER2阳性早期乳腺癌的生存率得到了显著提升。如何优化治疗模式和治疗策略,使患者达到最佳获益,是HER2阳性早期乳腺癌治疗领域的研究热点。本文将通过对HER2阳性早期乳腺癌新辅助和辅助治疗阶段的重要临床研究进行概述及分析,以期为未来制定HER2阳性早期乳腺癌的个体化治疗策略提供参考。

Reform and Prospect of Systemic Therapy on HER2-positive Early-stage Breast Cancer

In the past two decades, the survival of HER2-positive early-stage breast cancer patients has significantly improved with the development of HER2-targeted therapies. The focus has been placed on maximizing the clinical benefit of HER2-positive early-stage breast cancer by optimizing the treatment frameworks and therapeutic strategies in this field. In this paper, several important clinical studies of HER2-positive early-stage breast cancer in the neoadjuvant or adjuvant settings will be summarized and analyzed to provide clues for the development of personalized treatment strategies in the future. © 2023, CHINA RESEARCH ON PREVENTION AND TREATMENT. All rights reserved.