初始拉米夫定联合阿德福韦酯治疗乙肝肝硬化的效果

目的：观察初始拉米夫定联合阿德福韦酯治疗乙肝肝硬化的效果。方法：病例来源于2012年5月～2014年5月在医院门诊接受治疗的乙肝肝硬化患者80例，利用随机数字表法分为观察组和对照组，每组40例。观察组在口服初始拉米夫定的基础上，服用阿德福韦酯进行治疗。对照组口服初始拉米夫定药物治疗，治疗结束后，对两组的治疗效果及不良反应进行观察和评价。结果：两组患者乙肝病毒的检测结果由阳转阴的时间和治疗时间的差异具有统计学意义（P<0.05）。观察组总有效率为87.5%（35/40），对照组总有效率为55%（22/40），差异具有统计学意义（X2=7.75，P<0.05）。观察组不良反应发生率为5%（2/40），对照组不良反应发生率为27.5%（11/40），差异具有统计学意义（X2=7.73，P<0.05）。结论：联合使用拉米夫定和阿德福韦酯的有效率高于仅口服拉米夫定，不良反应发生率低于后者，而且能够明显减少治疗需要的时间，减轻患者痛苦，具有更高的安全性，能得到更好的治疗效果，值得临床推广。

The initial effect of adefovir combined with lamivudine treatment of hepatitis B cirrhosis

Objective:Initial analysis of lamivudine combined with adefovir treatment of hepatitis B cirrhosis effect. Methods:Cases from May 2012~2014 in May in our clinic treated 80 patients with liver cirrhosis. Using random number table included patients were divided into two groups and the control group, the corresponding figure is even random person group, odd as the control group, 40 cases in each group. Observation group were given on the basis of the initial oral lamivudine on, but also taking adefovir treatment. The control group received an initial grant of oral lamivudine therapy after the end of treatment, the treatment of the two groups and adverse effects were observed and evaluated. Results:Test results of hepatitis B virus in two groups of patients was statistically significant(P<0.05) by the time difference from positive to negative treatment time and observed total effective rate was 87.5%(35/40) in the control group was 55%(22/40), the difference was statistically significant(X2=7.75, P<0.05). Adverse reactions observed group was 5%(2/40) in the control group was 27.5% (11/40), the difference was statistically significant (X2=7.73,P<0.05). Conclusions:The joint use of lamivudine and adefovir are more than just oral lamivudine, and adverse reaction rates lower than the latter, and can significantly reduce the time required for treatment, and can reduce the suffering of patients, with higher security, to get better treatment, should be applied more and promotion in clinical practice.