Antiangiogenic activity of tumor necrosis factor-alpha production regulators derived from thalidomide |
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| Authors: | Shimazawa R Miyachi H Takayama H Kuroda K Kato F Kato M Hashimoto Y |
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| Affiliation: | Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan. |
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| Abstract: | ![]()
Recently, we developed novel tumor necrosis factor (TNF)-alpha production regulators with a phthalimide skeleton derived from thalidomide. We show here that some of these compounds are more potent inhibitors than thalidomide of angiogenesis induced by basic fibroblast growth factor in a murine angiogenesis assay. |
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