冠心病合并代谢综合征的冠脉病变特点及影响因素

目的探讨冠心病（CHD）合并代谢综合征（MS）患者危险因素与冠状动脉病变特点的相关性。方法回顾性分析经冠脉造影确诊的489例CHD患者,分为合并MS组患者与单纯CHD患者。分析冠脉病变影像资料与年龄、体重指数（BMI）、收缩压（SBP）、舒张压（DBP）、总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、LDL-C/HDL-C、TG/HDL-C、空腹血糖（FPG）、吸烟指数、血尿酸（UA）、纤维蛋白原（FIB）的关系。结果 CHD患者合并MS组冠脉病变以多支、重度为主且年龄较大,其更易合并糖尿病、高血压、血脂异常,较单纯CHD组有统计学意义（P〈0.05）。结论合并MS组非条件Logistic回归模型分析其主要危险因素有高血糖,CHD合并MS患者冠脉病变较重,其范围及严重程度与心血管多重危险因素聚集有关,更需加强防治。

The characteristic of coronary artery disease and influence factors in coronary heart disease with MS

Objective To investigate the relationship between the clinical risk factor and the characteristic of coronary artery disease in coronary heart disease with MS.Methods 489 patients with coronary heart disease（CHD） were retrospectively studied by case-control,who were divided into two groups.All patients were divided into two groups CHD with metabolic syndrome（MS） and CHD.The relationship between coronary artery disease and multiple risk factors in the patients with MS and CHD was investigated.Totally 489 patients were definitely diagnosed with CHD by coronary arteriography and their BMI,SBP,DBP,FPG,TC,TG,HDL-C,LDL-C,LDL-C/HDL-C,TG/HDL-C and UA were recorded.Results Risk factor were significantly higher in CHD with MS group than those in CHD group（P0.05）.The patients with more-vessel lesions were significantly higher in CHD with MS（P0.05）.Conclusion FPG is more severe in the CHD with MS group,and the severity and disease extent of coronary artery lesions relate with risk factor aggregation of Coronary Artery Disease with MS.