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| 高效液相色谱法测定血浆中洛美沙星浓度及其在人体内药代动力学 | |
| 引用本文： | 谭力,许丹科,刁勇,袁倚盛. 高效液相色谱法测定血浆中洛美沙星浓度及其在人体内药代动力学[J]. 药学学报, 1993, 28(4): 286-289 |
| 作者姓名： | 谭力 许丹科 刁勇 袁倚盛 |
| 作者单位： | 南京军区南京总医院中心仪器分析科，南京军区南京总医院中心仪器分析科，南京军区药品检验所，南京军区南京总医院中心仪器分析科 南京 210002，南京 210002，南京 210002，南京 210002 |
| 摘 要： | 建立了人血浆洛美沙星的反相离子对高效液相色谱测定方法。该法简便易行,精密度好,方法回收率95～102%,日内、日间RSD为2.1～7.8%,血药浓度在0.125～5.012 μg/ml范围内呈线性关系,相关系数0.9998,当S/N=2时,最小检测浓度为25 ng/ml。健康志愿者口服400 mg洛美沙星,药代动力学过程符合一室模型,消除相半衰期为5.5 h。 |
| 关 键 词： | 洛美沙星 高效液相色谱法 药代动力学 |
| 收稿时间： | 1992-07-07 |
HIGHPERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR LOMEFLOXACIN IN PLASMA AND ITS PHARMACOKINETICS IN HEALTHY VOLUNTEERS |
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| L Tan,DK Xu,Y Diao and YS Yuan. HIGHPERFORMANCE LIQUID CHROMATOGRAPHIC ASSAY FOR LOMEFLOXACIN IN PLASMA AND ITS PHARMACOKINETICS IN HEALTHY VOLUNTEERS[J]. Acta pharmaceutica Sinica, 1993, 28(4): 286-289 | |
| Authors: | L Tan DK Xu Y Diao YS Yuan |
| Abstract: | A sensitive and simplified high performance liquid chromatographic procedure has been developed for quantification of lomefloxacin in human plasma. The recovery of lomefloxacin was 95 to 102 %. The relative standard deviation was 2. 1 to 7. 8 %. The calibration curve was linear in the range from 0. 125 μg/ml to 5. 012 μg/ml with r=0. 9998. The detection limit of the method is 25 ng/ml. The plasma drug concentration--time course after medication conformed to a 1-compartment open model with a first order absorption. Mean t1/2 value was 5.5 h. |
| Keywords: | Lomefloxacin HPLC Pharmacokinetics |
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